2-[4-{3-(t-butyldimethylsilyloxy)propyl}-1-piperazinyl]-1-phenylethanol

Base Information

• Chemical Name: 2-[4-{3-(t-butyldimethylsilyloxy)propyl}-1-piperazinyl]-1-phenylethanol
• CAS No.: 105872-02-4
• Molecular Formula: C₂₁H₃₈N₂O₂Si
• Molecular Weight: 378.63

Synonyms:2-[4-{3-(t-butyldimethylsilyloxy)propyl}-1-piperazinyl]-1-phenylethanol

Chemical Property of 2-[4-{3-(t-butyldimethylsilyloxy)propyl}-1-piperazinyl]-1-phenylethanol

Chemical Property:

Purity/Quality:

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Technology Process of 2-[4-{3-(t-butyldimethylsilyloxy)propyl}-1-piperazinyl]-1-phenylethanol

There total 3 articles about 2-[4-{3-(t-butyldimethylsilyloxy)propyl}-1-piperazinyl]-1-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

1-(3-tert-butyldimethylsilyloxypropyl)-4-phenacylpiperazine (105871-99-6) → 2-[4-{3-(t-butyldimethylsilyloxy)propyl}-1-piperazinyl]-1-phenylethanol (105872-02-4)

Guidance literature:

With sodium borohydrid; In methanol;

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 2-[4-{3-(t-butyldimethylsilyloxy)propyl}-1-piperazinyl]-1-phenylethanol (105872-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: NaBH₄ / ethanol / 2 h / Ambient temperature

With sodium tetrahydroborate; triethylamine; In ethanol; dichloromethane;

DOI:10.1248/cpb.42.963

Reference yield:

1-(3-hydroxypropyl)-4-phenacylpiperazine (105871-98-5) → 2-[4-{3-(t-butyldimethylsilyloxy)propyl}-1-piperazinyl]-1-phenylethanol (105872-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: NaBH₄ / ethanol / 2 h / Ambient temperature

With sodium tetrahydroborate; triethylamine; In ethanol; dichloromethane;

DOI:10.1248/cpb.42.963

upstream raw materials:

1-(3-tert-butyldimethylsilyloxypropyl)-4-phenacylpiperazine

tert-butyldimethylsilyl chloride

1-(3-hydroxypropyl)-4-phenacylpiperazine

Downstream raw materials:

[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2-{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-piperazin-1-yl}-1-phenyl-ethyl ester

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