1H-Indole, 1-acetyl-6-(chloroacetyl)- (9CI)

Base Information

• Chemical Name: 1H-Indole, 1-acetyl-6-(chloroacetyl)- (9CI)
• CAS No.: 92013-04-2
• Molecular Formula: C12H10 Cl N O2
• Molecular Weight: 235.6663
• Mol file: 92013-04-2.mol

Synonyms:1H-Indole,1-acetyl-6-(chloroacetyl)- (9CI)

Chemical Property of 1H-Indole, 1-acetyl-6-(chloroacetyl)- (9CI)

Chemical Property:

• PSA: 39.07000
• LogP: 2.72290

Purity/Quality:

99% ^*data from raw suppliers

1-ACETYL-6-(CHLOROACETYL)-1H-INDOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole, 1-acetyl-6-(chloroacetyl)- (9CI)

There total 7 articles about 1H-Indole, 1-acetyl-6-(chloroacetyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-acetylindole (576-15-8) + chloroacetyl chloride (79-04-9) → 1-Acetyl-6-chloroacetylindole (92013-04-2)

Guidance literature:

With aluminium trichloride; at 10 - 15 ℃; for 1h;

DOI:10.1007/BF00472383

Reference yield: 71.0%

N-acetylindole (576-15-8) + Chloroacetic anhydride (541-88-8) → 1-Acetyl-6-chloroacetylindole (92013-04-2)

Guidance literature:

With aluminium trichloride; In dichloromethane; at 20 ℃;

DOI:10.1016/S0040-4039(00)02313-3

Reference yield: 37.0%

1-acetyl-4-(trimethylsilyl)indole (83188-12-9) + chloroacetyl chloride (79-04-9) → 1-Acetyl-6-chloroacetylindole (92013-04-2) + 1-acetyl-6-(chloroacetyl)-4-(trimethylsilyl)indole (92013-03-1)

Guidance literature:

With aluminium trichloride; In dichloromethane; for 15h; Ambient temperature;

DOI:10.1021/jo00197a016

upstream raw materials:

N-acetylindole

chloroacetyl chloride

1-acetyl-4-(trimethylsilyl)indole

Chloroacetic anhydride

Downstream raw materials:

6-Chloroacetylindole

Refernces

• 1、 Nakatsuka, Shin-ishi,Teranishi, Katsunori,Goto, Toshio. "FORMATION OF 6-ACYLINDOLES FROM 1-ACYLINDOLES". . p. 2699 - 2700. Retrieved 2007/10/02.
• 2、 Barrett, Anthony G. M.,Dauzonne, Daniel,O'Neil, Ian A.,Renaud, Alain. "Preparation and Reactions of 4-(Trimethylsilyl)indole". . p. 4409 - 4415. Retrieved 2007/10/02.