(1S,8aS)-7,7-bis(2-hydroxyethyl)-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Base Information

Chemical Name:(1S,8aS)-7,7-bis(2-hydroxyethyl)-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide
CAS No.:1453069-28-7
Molecular Formula:C₃₂H₄₂F₃N₃O₄
Molecular Weight:589.698
Hs Code.:

(1S,8aS)-7,7-bis(2-hydroxyethyl)-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Synonyms:(1S,8aS)-7,7-bis(2-hydroxyethyl)-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,8aS)-7,7-bis(2-hydroxyethyl)-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1S,8aS)-7,7-bis(2-hydroxyethyl)-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

There total 18 articles about (1S,8aS)-7,7-bis(2-hydroxyethyl)-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1453070-48-8
(1S,8aS)-7,7-diallyl-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

: 1453069-28-7
(1S,8aS)-7,7-bis(2-hydroxyethyl)-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Guidance literature:: (1S,8aS)-7,7-diallyl-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide; With oxygen; ozone; In dichloromethane; at -78 ℃;

With sodium tetrahydroborate; In dichloromethane; at -78 - 20 ℃; for 20h; Inert atmosphere;

Reference yield:

: 328-67-6
3-bromo-5-(trifluoromethyl)benzoic acid

: 1453069-28-7
(1S,8aS)-7,7-bis(2-hydroxyethyl)-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 °C

2.1: triethylamine / dichloromethane / 1 h / 0 °C

3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.33 h / -40 - 20 °C

4.1: titanium(IV) isopropylate / tetrahydrofuran / 6 h / 0 - 20 °C

5.1: dichloromethane; tetrahydrofuran / 2 h / -40 - 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -60 °C / Inert atmosphere

6.2: 1 h / -60 - 20 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 4 h / Inert atmosphere; Reflux

8.1: palladium on activated charcoal; hydrogen / methanol / 24 h / 20 °C / 2585.81 Torr / Inert atmosphere

9.1: hydrogenchloride / methanol / 1 h / Inert atmosphere

10.1: triethylamine; dmap / ethyl acetate / 1.5 h / 0 °C

10.2: 48 h / 50 °C

11.1: ozone; oxygen / dichloromethane / -78 °C

11.2: 20 h / -78 - 20 °C / Inert atmosphere

With titanium(IV) isopropylate; hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; palladium on activated charcoal; hydrogen; oxygen; diisobutylaluminium hydride; ozone; triethylamine; N,N-dimethyl-formamide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; toluene;

Reference yield:

: 880652-44-8
3-bromo-N-methoxy-N-methyl-5-(trifluoromethyl)benzamide

: 1453069-28-7
(1S,8aS)-7,7-bis(2-hydroxyethyl)-N-((R)-1-(3-isopropyl-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.33 h / -40 - 20 °C

2.1: titanium(IV) isopropylate / tetrahydrofuran / 6 h / 0 - 20 °C

3.1: dichloromethane; tetrahydrofuran / 2 h / -40 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -60 °C / Inert atmosphere

4.2: 1 h / -60 - 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 4 h / Inert atmosphere; Reflux

6.1: palladium on activated charcoal; hydrogen / methanol / 24 h / 20 °C / 2585.81 Torr / Inert atmosphere

7.1: hydrogenchloride / methanol / 1 h / Inert atmosphere

8.1: triethylamine; dmap / ethyl acetate / 1.5 h / 0 °C

8.2: 48 h / 50 °C

9.1: ozone; oxygen / dichloromethane / -78 °C

9.2: 20 h / -78 - 20 °C / Inert atmosphere

With titanium(IV) isopropylate; hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydrogen; oxygen; diisobutylaluminium hydride; ozone; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; toluene;