5-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-3-thienyl)-2-thiophenesulfonamide

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Chemical Name:5-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-3-thienyl)-2-thiophenesulfonamide
CAS No.:1089669-65-7
Molecular Formula:C₂₂H₁₉F₂N₃O₆S₄
Molecular Weight:587.67
Hs Code.:

Synonyms:5-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-3-thienyl)-2-thiophenesulfonamide

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Chemical Property of 5-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-3-thienyl)-2-thiophenesulfonamide

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Technology Process of 5-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-3-thienyl)-2-thiophenesulfonamide

There total 8 articles about 5-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-3-thienyl)-2-thiophenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1089669-63-5
2-(difluoromethyl)-4-[5-(1H-imidazol-1-ylsulfonyl)-2-thienyl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 6338-70-1
3-amino-tetrahydrothiophene 1,1-dioxide

: 1089669-65-7
5-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-3-thienyl)-2-thiophenesulfonamide

Guidance literature:: 2-(difluoromethyl)-4-[5-(1H-imidazol-1-ylsulfonyl)-2-thienyl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; With methyl trifluoromethanesulfonate; In tetrahydrofuran; at 0 ℃; for 0.5h;

3-amino-tetrahydrothiophene 1,1-dioxide; In tetrahydrofuran; at 20 ℃; for 0.5h;

With 1-Methylpyrrolidine; In tetrahydrofuran; for 0.5h;

Reference yield:

: 1014613-45-6
[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]boronic acid

: 1089669-65-7
5-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-3-thienyl)-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 120 °C / Microwave irradiation

2.1: methyl trifluoromethanesulfonate / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.5 h / 20 °C

2.3: 0.5 h

With sodium carbonate; methyl trifluoromethanesulfonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 889939-25-7
1-(benzenesulfonyl)-4-bromo-1H-pyrrolo[2,3-b]pyridine

: 1089669-65-7
5-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-3-thienyl)-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.67 h / 20 °C

1.2: -30 - 20 °C

2.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexanes / 4.17 h / -78 - 20 °C

4.1: hydrogenchloride; water / tetrahydrofuran; hexanes / 0.17 h / -78 °C

5.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 120 °C / Microwave irradiation

6.1: methyl trifluoromethanesulfonate / tetrahydrofuran / 0.5 h / 0 °C

6.2: 0.5 h / 20 °C

6.3: 0.5 h

With hydrogenchloride; n-butyllithium; water; sodium carbonate; methyl trifluoromethanesulfonate; (bis-(2-methoxyethyl)amino)sulfur trufluoride; lithium diisopropyl amide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; hexanes; n-heptane; dichloromethane; ethylbenzene; water;