(R)-N-(benzyloxy)-N-(3-((2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)amino)propyl)formamide

Base Information

Chemical Name:(R)-N-(benzyloxy)-N-(3-((2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)amino)propyl)formamide
CAS No.:1454273-63-2
Molecular Formula:C₄₃H₄₂F₇N₅O₆
Molecular Weight:857.825
Hs Code.:

(R)-N-(benzyloxy)-N-(3-((2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)amino)propyl)formamide

Synonyms:(R)-N-(benzyloxy)-N-(3-((2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)amino)propyl)formamide

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Chemical Property of (R)-N-(benzyloxy)-N-(3-((2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)amino)propyl)formamide

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Technology Process of (R)-N-(benzyloxy)-N-(3-((2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)amino)propyl)formamide

There total 3 articles about (R)-N-(benzyloxy)-N-(3-((2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)amino)propyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1454272-05-9
(R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione

: 1454273-62-1
N-(benzyloxy)-N-(3-bromopropyl)formamide

: 1454273-63-2
(R)-N-(benzyloxy)-N-(3-((2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)amino)propyl)formamide

Guidance literature:: With potassium carbonate; sodium iodide; In acetonitrile;

Reference yield:

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 1454273-63-2
(R)-N-(benzyloxy)-N-(3-((2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)amino)propyl)formamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h / 20 °C

1.2: 3.5 h / 20 °C

2.1: potassium carbonate / acetonitrile / 14 h / 60 °C

3.1: sodium iodide; potassium carbonate / acetonitrile

With potassium carbonate; 1,1'-carbonyldiimidazole; sodium iodide; In dichloromethane; acetonitrile;

Reference yield:

: 183991-46-0
N-formyl-N-benzyloxyamine

: 1454273-63-2
(R)-N-(benzyloxy)-N-(3-((2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-phenylethyl)amino)propyl)formamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 14 h / 60 °C

2: sodium iodide; potassium carbonate / acetonitrile

With potassium carbonate; sodium iodide; In acetonitrile;