1-(2-Hydroxy-2-phenylethyl)-4-(N-propionylanilino)piperidin-4-carbonsaeure-methylester-oxalat

Base Information

• Chemical Name: 1-(2-Hydroxy-2-phenylethyl)-4-(N-propionylanilino)piperidin-4-carbonsaeure-methylester-oxalat
• CAS No.: 61086-47-3
• Molecular Formula: C₂H₂O₄*C₂₄H₃₀N₂O₄
• Molecular Weight: 500.549
• Mol file: 61086-47-3.mol

Synonyms:1-(2-Hydroxy-2-phenylethyl)-4-(N-propionylanilino)piperidin-4-carbonsaeure-methylester-oxalat

Chemical Property of 1-(2-Hydroxy-2-phenylethyl)-4-(N-propionylanilino)piperidin-4-carbonsaeure-methylester-oxalat

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-Hydroxy-2-phenylethyl)-4-(N-propionylanilino)piperidin-4-carbonsaeure-methylester-oxalat

There total 3 articles about 1-(2-Hydroxy-2-phenylethyl)-4-(N-propionylanilino)piperidin-4-carbonsaeure-methylester-oxalat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

C24H28N2O4*C2H2O4 + oxalic acid (144-62-7,97993-78-7) → 1-(2-Hydroxy-2-phenylethyl)-4-(N-propionylanilino)piperidin-4-carbonsaeure-methylester-oxalat (61086-47-3)

Guidance literature:

C₂₄H₂₈N₂O₄*C₂H₂O₄; With sodium hydrogencarbonate; In chloroform; water; at 20 ℃; for 1h;

With methanol; sodium tetrahydroborate; for 6h; Cooling with ice;

oxalic acid; In isopropyl alcohol; for 16h; Cooling;

DOI:10.1021/acsmedchemlett.9b00404

Reference yield:

methyl 4-[N-(1-oxopropyl)-N-phenylamino]-4-piperidinecarboxylate (72996-78-2) + α-bromoacetophenone (70-11-1) → 1-(2-Hydroxy-2-phenylethyl)-4-(N-propionylanilino)piperidin-4-carbonsaeure-methylester-oxalat (61086-47-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / butanone / 16 h / Reflux

1.2: 16 h / Cooling

2.1: sodium hydrogencarbonate / water; chloroform / 1 h / 20 °C

2.2: 6 h / Cooling with ice

2.3: 16 h / Cooling

With sodium hydrogencarbonate; potassium carbonate; In chloroform; water; butanone;

DOI:10.1021/acsmedchemlett.9b00404

Reference yield:

→ 1-(2-Hydroxy-2-phenylethyl)-4-(N-propionylanilino)piperidin-4-carbonsaeure-methylester-oxalat (61086-47-3)

Guidance literature:

N¹-H-Verb., 2-Phenyloxiran;

upstream raw materials:

oxalic acid

methyl 4-[N-(1-oxopropyl)-N-phenylamino]-4-piperidinecarboxylate

α-bromoacetophenone