MPEP

Base Information

Chemical Name:MPEP
CAS No.:96206-92-7
Molecular Formula:C14H11 N
Molecular Weight:193.248
Hs Code.:2933399090
UNII:7VC0YVI27Y
DSSTox Substance ID:DTXSID7042564
Nikkaji Number:J1.127.376I
Wikipedia:2-Methyl-6-(phenylethynyl)pyridine
Wikidata:Q4596902
Pharos Ligand ID:8HF7HCHGHYVA
Metabolomics Workbench ID:63194
ChEMBL ID:CHEMBL66654
Mol file:96206-92-7.mol

Synonyms:2-Picoline,6-phenylethynyl- (6CI); Pyridine, 2-methyl-6-(phenylethynyl)- (9CI);2-Methyl-6-(phenylethynyl)pyridine; MPEP

Suppliers and Price of MPEP

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
MPEP hydrochloride
10mg
$ 403.00

Tocris
MPEPhydrochloride ≥99%(HPLC)
50
$ 611.00

Tocris
MPEPhydrochloride ≥99%(HPLC)
10
$ 150.00

Sigma-Aldrich
MPEP Hydrochloride - CAS 96206-92-7 - Calbiochem
10 mg
$ 200.00

Sigma-Aldrich
MPEP Hydrochloride - CAS 96206-92-7 - Calbiochem
5046350001
$ 193.00

DC Chemicals
MPEP >98.5%
100 mg
$ 300.00

Crysdot
MPEP 98+%
50mg
$ 139.00

Biosynth Carbosynth
MPEP
50 mg
$ 227.50

Biosynth Carbosynth
MPEP
10 mg
$ 65.00

Biorbyt Ltd
MPEP HCl >98%
5 mg
$ 127.50

Total 33 raw suppliers

Chemical Property of MPEP

Chemical Property:

Vapor Pressure:0.000221mmHg at 25°C
Melting Point:45-45.5 °C
Boiling Point:336.3°Cat760mmHg
PKA:2.97±0.12(Predicted)
Flash Point:144.8°C
PSA：12.89000
Density:g/cm³
LogP:3.59180
Storage Temp.:Desiccate at +4°C
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:193.089149355
Heavy Atom Count:15
Complexity:251

Purity/Quality:

97% ^*data from raw suppliers

MPEP hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC(=CC=C1)C#CC2=CC=CC=C2
Uses A potent, subtype selective mGluR5 antagonist 2-Methyl-6-(2-phenylethynyl)pyridine induces pathophysiological mGluR5 signaling in Alzheimer''s disease model mice in sex-selective manner.

Technology Process of MPEP

There total 11 articles about MPEP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 18368-63-3
6-chloro-2-picoline

: 1719-19-3
2-Methyl-4-phenyl-3-butyn-2-ol

: 96206-92-7
2-methyl-6-(phenylethynyl)pyridine

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; palladium dichloride; XPhos; In water; at 120 ℃; Inert atmosphere; Schlenk technique; Green chemistry;
DOI:10.1080/00397911.2017.1297457

Reference yield: 91.0%

: 5315-25-3
2-bromo-6-methylpyridine

: 536-74-3
phenylacetylene

: 96206-92-7
2-methyl-6-(phenylethynyl)pyridine

Guidance literature:: 2-bromo-6-methylpyridine; With bis(η3-allyl-μ-chloropalladium(II)); 1-n-butyl-3-methylimidazolium tetrafluoroborate; triphenylphosphine; at 60 ℃; Inert atmosphere;

phenylacetylene; With pyrrolidine; at 100 ℃; for 4h; Inert atmosphere;
DOI:10.1055/s-0031-1289861

Reference yield: 88.0%

: 5315-24-2
1-(6-methylpyridin-2-yl)hydrazine

: 536-74-3
phenylacetylene

: 96206-92-7
2-methyl-6-(phenylethynyl)pyridine

Guidance literature:: With oxygen; potassium carbonate; copper(l) chloride; In methanol; at 25 - 28 ℃; for 10h; Irradiation; Green chemistry;
DOI:10.1039/c8gc01180j