(2S,3R)-1-(1'-benzyloxycarbonyl-2'-methylpropen-1'-yl)-2-acetyloxy-3-[3'-(o-chlorophenyl)-5'-methyl-5'-isoxazol-4'yl]carbonylamino-4-oxoazetidine

Base Information

Chemical Name:(2S,3R)-1-(1'-benzyloxycarbonyl-2'-methylpropen-1'-yl)-2-acetyloxy-3-[3'-(o-chlorophenyl)-5'-methyl-5'-isoxazol-4'yl]carbonylamino-4-oxoazetidine
CAS No.:446264-41-1
Molecular Formula:C₂₈H₂₆ClN₃O₇
Molecular Weight:551.983
Hs Code.:

Synonyms:(2S,3R)-1-(1'-benzyloxycarbonyl-2'-methylpropen-1'-yl)-2-acetyloxy-3-[3'-(o-chlorophenyl)-5'-methyl-5'-isoxazol-4'yl]carbonylamino-4-oxoazetidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-1-(1'-benzyloxycarbonyl-2'-methylpropen-1'-yl)-2-acetyloxy-3-[3'-(o-chlorophenyl)-5'-methyl-5'-isoxazol-4'yl]carbonylamino-4-oxoazetidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S,3R)-1-(1'-benzyloxycarbonyl-2'-methylpropen-1'-yl)-2-acetyloxy-3-[3'-(o-chlorophenyl)-5'-methyl-5'-isoxazol-4'yl]carbonylamino-4-oxoazetidine

There total 6 articles about (2S,3R)-1-(1'-benzyloxycarbonyl-2'-methylpropen-1'-yl)-2-acetyloxy-3-[3'-(o-chlorophenyl)-5'-methyl-5'-isoxazol-4'yl]carbonylamino-4-oxoazetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.4%

: 64-19-7,77671-22-8
acetic acid

: (1R,5R)-7-oxo-3-[3'-(o-chlorophenyl)-5'-methylisoxazol-4'yl]-4-oxa-2,6-diazabicyclo[3.2.0]hept-2-en-6-(1-'-benzyloxycarbonyl-2'-methyl)propen-1'-yl

: 446264-41-1
(2S,3R)-1-(1'-benzyloxycarbonyl-2'-methylpropen-1'-yl)-2-acetyloxy-3-[3'-(o-chlorophenyl)-5'-methyl-5'-isoxazol-4'yl]carbonylamino-4-oxoazetidine

Guidance literature:: With hydrogenchloride; In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 100-39-0
benzyl bromide

: 446264-41-1
(2S,3R)-1-(1'-benzyloxycarbonyl-2'-methylpropen-1'-yl)-2-acetyloxy-3-[3'-(o-chlorophenyl)-5'-methyl-5'-isoxazol-4'yl]carbonylamino-4-oxoazetidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 67.6 percent / dimethylformamide / 5 h / 20 °C

2.1: 66.5 percent / aq. H₂O₂; AcOH / 10 h / 20 °C

3.1: NCS / toluene / 1.5 h / Heating

3.2: toluene / 3 h / 20 °C

4.1: 62 percent / NCS / CH₂Cl₂ / 2 h / 20 °C

5.1: 20.4 percent / HCl (g) / CH₂Cl₂ / 20 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; dihydrogen peroxide; acetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 642-78-4
cloxacillin sodium

: 446264-41-1
(2S,3R)-1-(1'-benzyloxycarbonyl-2'-methylpropen-1'-yl)-2-acetyloxy-3-[3'-(o-chlorophenyl)-5'-methyl-5'-isoxazol-4'yl]carbonylamino-4-oxoazetidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 67.6 percent / dimethylformamide / 5 h / 20 °C

2.1: 66.5 percent / aq. H₂O₂; AcOH / 10 h / 20 °C

3.1: NCS / toluene / 1.5 h / Heating

3.2: toluene / 3 h / 20 °C

4.1: 62 percent / NCS / CH₂Cl₂ / 2 h / 20 °C

5.1: 20.4 percent / HCl (g) / CH₂Cl₂ / 20 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; dihydrogen peroxide; acetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;