methyl 3-[4-(cyclopropylcarbamoyl)phenyl]-8-[(2-methylpropyl)amino]-6-phenylimidazo[1,2-a]pyrazine-2-carboxylate

Base Information

Chemical Name:methyl 3-[4-(cyclopropylcarbamoyl)phenyl]-8-[(2-methylpropyl)amino]-6-phenylimidazo[1,2-a]pyrazine-2-carboxylate
CAS No.:1382451-59-3
Molecular Formula:C₂₈H₂₉N₅O₃
Molecular Weight:483.57
Hs Code.:

Synonyms:methyl 3-[4-(cyclopropylcarbamoyl)phenyl]-8-[(2-methylpropyl)amino]-6-phenylimidazo[1,2-a]pyrazine-2-carboxylate

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Chemical Property of methyl 3-[4-(cyclopropylcarbamoyl)phenyl]-8-[(2-methylpropyl)amino]-6-phenylimidazo[1,2-a]pyrazine-2-carboxylate

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Technology Process of methyl 3-[4-(cyclopropylcarbamoyl)phenyl]-8-[(2-methylpropyl)amino]-6-phenylimidazo[1,2-a]pyrazine-2-carboxylate

There total 7 articles about methyl 3-[4-(cyclopropylcarbamoyl)phenyl]-8-[(2-methylpropyl)amino]-6-phenylimidazo[1,2-a]pyrazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1382451-89-9
N-cyclopropyl-4-{2-formyl-8-[(2-methylpropyl)amino]-6-phenylimidazo[1,2-a]pyrazin-3-yl}benzamide

: 1382451-59-3
methyl 3-[4-(cyclopropylcarbamoyl)phenyl]-8-[(2-methylpropyl)amino]-6-phenylimidazo[1,2-a]pyrazine-2-carboxylate

Guidance literature:: With sodium cyanide; manganese(IV) oxide;

Reference yield:

: 87597-21-5
ethyl 6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate

: 1382451-59-3
methyl 3-[4-(cyclopropylcarbamoyl)phenyl]-8-[(2-methylpropyl)amino]-6-phenylimidazo[1,2-a]pyrazine-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisobutylaluminium hydride / toluene / 0 - 20 °C

2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 - 60 °C

3.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 0.5 h / 100 °C / microwave radiation

4.1: N,N-dimethyl-formamide / 3 h / 23 °C

5.1: potassium carbonate; triphenylphosphine / water; propan-1-ol / 2 h / 120 °C / microwave irradiation

6.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 2.33 h / -78 °C / Inert atmosphere

6.2: 1 h

7.1: manganese(IV) oxide; sodium cyanide

With sodium cyanide; manganese(IV) oxide; potassium phosphate; N-iodo-succinimide; oxalyl dichloride; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; propan-1-ol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1382451-66-2
(6,8-dibromoimidazo[1,2-a]pyrazin-2-yl)methanol

: 1382451-59-3
methyl 3-[4-(cyclopropylcarbamoyl)phenyl]-8-[(2-methylpropyl)amino]-6-phenylimidazo[1,2-a]pyrazine-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 - 60 °C

2.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 0.5 h / 100 °C / microwave radiation

3.1: N,N-dimethyl-formamide / 3 h / 23 °C

4.1: potassium carbonate; triphenylphosphine / water; propan-1-ol / 2 h / 120 °C / microwave irradiation

5.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 2.33 h / -78 °C / Inert atmosphere

5.2: 1 h

6.1: manganese(IV) oxide; sodium cyanide

With sodium cyanide; manganese(IV) oxide; potassium phosphate; N-iodo-succinimide; oxalyl dichloride; potassium carbonate; triphenylphosphine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; propan-1-ol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;