ethyl benzimidate-2,3,4,5,6-d₅

Base Information

• Chemical Name: ethyl benzimidate-2,3,4,5,6-d₅
• CAS No.: 1441098-35-6
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 154.153
• Mol file: 1441098-35-6.mol

Synonyms:ethyl benzimidate-2,3,4,5,6-d₅

Chemical Property of ethyl benzimidate-2,3,4,5,6-d₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl benzimidate-2,3,4,5,6-d₅

There total 2 articles about ethyl benzimidate-2,3,4,5,6-d₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethanol (64-17-5) + perdeuterated cyanobenzene (2102-15-0) → ethyl benzimidate-2,3,4,5,6-d5 (1441098-35-6)

Guidance literature:

With acetyl chloride; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/adsc.201600128

Reference yield:

bromobenzene-d5 (4165-57-5) → ethyl benzimidate-2,3,4,5,6-d5 (1441098-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene; sodium carbonate / 1-methyl-pyrrolidin-2-one / 16 h / 120 °C / Inert atmosphere

2: acetyl chloride / 24 h / 20 °C / Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; sodium carbonate; acetyl chloride; In 1-methyl-pyrrolidin-2-one;

DOI:10.1002/adsc.201600128

Reference yield: 71.0%

phosgene (75-44-5) + ethyl benzimidate-2,3,4,5,6-d5 (1441098-35-6) → C10H5(2)H5ClNO2

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 18h;

upstream raw materials:

ethanol

perdeuterated cyanobenzene

bromobenzene-d5

Downstream raw materials:

perdeuterated cyanobenzene