(R)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-3-(2-methoxy-phenyl)-N-methyl-propionamide

Base Information

Chemical Name:(R)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-3-(2-methoxy-phenyl)-N-methyl-propionamide
CAS No.:170642-25-8
Molecular Formula:C₂₀H₂₆N₂O₃
Molecular Weight:342.438
Hs Code.:

Synonyms:(R)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-3-(2-methoxy-phenyl)-N-methyl-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-3-(2-methoxy-phenyl)-N-methyl-propionamide

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Technology Process of (R)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-3-(2-methoxy-phenyl)-N-methyl-propionamide

There total 10 articles about (R)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-3-(2-methoxy-phenyl)-N-methyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52289-93-7
o-Methoxybenzyl bromide

: 170115-96-5
2-amino-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylacetamide

: (S)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-3-(2-methoxy-phenyl)-N-methyl-propionamide

: 170642-25-8
(R)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-3-(2-methoxy-phenyl)-N-methyl-propionamide

Guidance literature:: With n-butyllithium; lithium chloride; In tetrahydrofuran; hexane; at 0 ℃; for 2h; Yield given. Yields of byproduct given;
DOI:10.1021/ja9624073

Reference yield:

: 52289-93-7
o-Methoxybenzyl bromide

: 170642-25-8
(R)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-3-(2-methoxy-phenyl)-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA, LiCl, 3.) aq. NaOH, 4.) aq. sodium bicarbonate

2: 1.) n-BuLi, LiCl

3: 1.) LDA, LiCl / 1.) THF, -78 deg C, 2.) THF, 0 deg C, 2 h

With sodium hydroxide; n-butyllithium; sodium hydrogencarbonate; lithium chloride; lithium diisopropyl amide;
DOI:10.1021/ja00137a034

Reference yield:

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 170642-25-8
(R)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-3-(2-methoxy-phenyl)-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: n-BuLi, LiCl / hexane; tetrahydrofuran / 1 h / 0 °C

2: n-BuLi, LiCl / tetrahydrofuran; hexane / 2 h / 0 °C

With n-butyllithium; lithium chloride; In tetrahydrofuran; hexane;
DOI:10.1021/ja9624073