2-(4-acetylphenyl)-2,2-difluoroacetic acid

Base Information

• Chemical Name: 2-(4-acetylphenyl)-2,2-difluoroacetic acid
• CAS No.: 1308915-16-3
• Molecular Formula: C₁₀H₈F₂O₃
• Molecular Weight: 214.169
• Hs Code.: 2918300090
• Mol file: 1308915-16-3.mol

Synonyms:2-(4-acetylphenyl)-2,2-difluoroacetic acid

Chemical Property of 2-(4-acetylphenyl)-2,2-difluoroacetic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Acetylphenyl)-2,2-difluoroacetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-acetylphenyl)-2,2-difluoroacetic acid

There total 9 articles about 2-(4-acetylphenyl)-2,2-difluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-(4-acetylphenyl)-2,2-difluoroacetic acid ethyl ester (1308915-15-2) → 2-(4-acetylphenyl)-2,2-difluoroacetic acid (1308915-16-3)

Guidance literature:

2-(4-acetylphenyl)-2,2-difluoroacetic acid ethyl ester; With water; sodium hydroxide; at 100 ℃; for 1.5h;

With hydrogenchloride; In water;

Reference yield: 64.0%

4-Iodoacetophenone (13329-40-3) + Ethyl bromodifluoroacetate (667-27-6) → 2-(4-acetylphenyl)-2,2-difluoroacetic acid (1308915-16-3)

Guidance literature:

4-Iodoacetophenone; Ethyl bromodifluoroacetate; With copper; In dimethyl sulfoxide; at 60 ℃; for 12h;

With potassium carbonate; In methanol; at 20 ℃; for 2h;

DOI:10.1021/acs.orglett.6b01188

Reference yield:

4-Iodoacetophenone (13329-40-3) → 2-(4-acetylphenyl)-2,2-difluoroacetic acid (1308915-16-3)

Guidance literature:

Multi-step reaction with 2 steps

1: copper / dimethyl sulfoxide / 24 h / 55 °C / Inert atmosphere

2: sodium hydroxide; water / 1.5 h / 100 °C

With water; sodium hydroxide; copper; In dimethyl sulfoxide; 1: Kumadaki method;

upstream raw materials:

4-Iodoacetophenone

2-(4-acetylphenyl)-2,2-difluoroacetic acid ethyl ester

1-bromo-4-(1,1-diethoxyethyl)benzene

Ethyl bromodifluoroacetate

Downstream raw materials:

1-(4-trifluoromethylphenyl)ethanone

1-(4-(difluoromethyl)phenyl)ethan-1-one