2-(4-acetylphenyl)-2,2-difluoroacetic acid ethyl ester

Base Information

• Chemical Name: 2-(4-acetylphenyl)-2,2-difluoroacetic acid ethyl ester
• CAS No.: 1308915-15-2
• Molecular Formula: C₁₂H₁₂F₂O₃
• Molecular Weight: 242.222
• Hs Code.: 2918300090
• Mol file: 1308915-15-2.mol

Synonyms:2-(4-acetylphenyl)-2,2-difluoroacetic acid ethyl ester

Chemical Property of 2-(4-acetylphenyl)-2,2-difluoroacetic acid ethyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 2-(4-acetylphenyl)-2,2-difluoroacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-acetylphenyl)-2,2-difluoroacetic acid ethyl ester

There total 9 articles about 2-(4-acetylphenyl)-2,2-difluoroacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-Iodoacetophenone (13329-40-3) + Ethyl bromodifluoroacetate (667-27-6) → 2-(4-acetylphenyl)-2,2-difluoroacetic acid ethyl ester (1308915-15-2)

Guidance literature:

With copper; In dimethyl sulfoxide; at 60 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ol4009377

Reference yield: 78.0%

Ethyl bromodifluoroacetate (667-27-6) + acetophenone (98-86-2) → 2-(4-acetylphenyl)-2,2-difluoroacetic acid ethyl ester (1308915-15-2)

Guidance literature:

With (bis(tricyclohexyl)phosphine)palladium(II) dichloride; iron(II) acetate; potassium carbonate; In 1,2-dichloro-ethane; at 110 ℃; for 48h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1039/c8cc09129c

Reference yield: 77.0%

Ethyl bromodifluoroacetate (667-27-6) + C19H24ClNORu → 2-(4-acetylphenyl)-2,2-difluoroacetic acid ethyl ester (1308915-15-2)

Guidance literature:

With (2S,3S)-N-acetyl-2-amino-3-methylpentanoic acid; sodium carbonate; silver(I) triflimide; In 1,2-dichloro-ethane; at 150 ℃; for 48h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201711221

upstream raw materials:

4-Iodoacetophenone

Ethyl bromodifluoroacetate

p-ethoxycarbonylphenylboronic acid

p-aminobenzophenone

Downstream raw materials:

2-(4-acetylphenyl)-2,2-difluoroacetic acid

1-(4-(difluoromethyl)phenyl)ethan-1-one

1-(4-trifluoromethylphenyl)ethanone

C₁₆H₁₀F₂N₂O₂