2-Ethyl-4-{4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-phenyl}-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Base Information

Chemical Name:2-Ethyl-4-{4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-phenyl}-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one
CAS No.:74852-93-0
Molecular Formula:C₂₂H₂₇N₅O₂
Molecular Weight:393.489
Hs Code.:

Synonyms:2-Ethyl-4-{4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-phenyl}-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

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Chemical Property of 2-Ethyl-4-{4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-phenyl}-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

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Technology Process of 2-Ethyl-4-{4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-phenyl}-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

There total 7 articles about 2-Ethyl-4-{4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-phenyl}-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 74-96-4
ethyl bromide

: 74852-90-7
2,4-dihydro-4-{4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl}-5-methyl-3H-1,2,4-triazol-3-one

: 74852-93-0
2-Ethyl-4-{4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-phenyl}-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: With potassium hydroxide; In dimethyl sulfoxide; for 14h;
DOI:10.1021/jm00373a015

Reference yield:

: 100-00-5
4-chlorobenzonitrile

: 74852-93-0
2-Ethyl-4-{4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-phenyl}-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: 67 percent / K₂CO₃ / dimethylsulfoxide / 120 °C

2: 74 percent / H₂, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating

3: 61 percent / pyridine / CHCl₃ / 3 h

4: 63 percent / hydrazine hydrate / dioxane / 3 h / Heating

5: 34 percent / NaOAc / butan-1-ol

6: 80 percent / KOH / dimethylsulfoxide / 14 h

With thiophene; pyridine; potassium hydroxide; hydrogen; sodium acetate; potassium carbonate; hydrazine hydrate; palladium on activated charcoal; In 1,4-dioxane; methanol; chloroform; 2-methoxy-ethanol; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/jm00373a015

Reference yield:

: 38212-30-5
4-(4-methoxyphenyl)piperazine

: 74852-93-0
2-Ethyl-4-{4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-phenyl}-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: 67 percent / K₂CO₃ / dimethylsulfoxide / 120 °C

2: 74 percent / H₂, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating

3: 61 percent / pyridine / CHCl₃ / 3 h

4: 63 percent / hydrazine hydrate / dioxane / 3 h / Heating

5: 34 percent / NaOAc / butan-1-ol

6: 80 percent / KOH / dimethylsulfoxide / 14 h

With thiophene; pyridine; potassium hydroxide; hydrogen; sodium acetate; potassium carbonate; hydrazine hydrate; palladium on activated charcoal; In 1,4-dioxane; methanol; chloroform; 2-methoxy-ethanol; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/jm00373a015