benzyl 4-[3-(3-{2-[(3-methoxy-2-{[(4-methyl-phenyl)-sulfonyl]amino}-3-oxopropyl)amino]-2-oxoethyl}-1H-1-indolyl)propyl]-1-piperidinecarboxylate

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Chemical Name:benzyl 4-[3-(3-{2-[(3-methoxy-2-{[(4-methyl-phenyl)-sulfonyl]amino}-3-oxopropyl)amino]-2-oxoethyl}-1H-1-indolyl)propyl]-1-piperidinecarboxylate
CAS No.:461052-63-1
Molecular Formula:C₃₇H₄₄N₄O₇S
Molecular Weight:688.845
Hs Code.:

Synonyms:benzyl 4-[3-(3-{2-[(3-methoxy-2-{[(4-methyl-phenyl)-sulfonyl]amino}-3-oxopropyl)amino]-2-oxoethyl}-1H-1-indolyl)propyl]-1-piperidinecarboxylate

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Chemical Property of benzyl 4-[3-(3-{2-[(3-methoxy-2-{[(4-methyl-phenyl)-sulfonyl]amino}-3-oxopropyl)amino]-2-oxoethyl}-1H-1-indolyl)propyl]-1-piperidinecarboxylate

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Technology Process of benzyl 4-[3-(3-{2-[(3-methoxy-2-{[(4-methyl-phenyl)-sulfonyl]amino}-3-oxopropyl)amino]-2-oxoethyl}-1H-1-indolyl)propyl]-1-piperidinecarboxylate

There total 5 articles about benzyl 4-[3-(3-{2-[(3-methoxy-2-{[(4-methyl-phenyl)-sulfonyl]amino}-3-oxopropyl)amino]-2-oxoethyl}-1H-1-indolyl)propyl]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: methyl 2-(S)-tosylamino-3-aminopropanoate hydrochloride

: 461052-34-6
4-[3-(3-carboxymethyl-indol-1-yl)-propyl]-piperidine-1-carboxylic acid benzyl ester

: 461052-63-1
benzyl 4-[3-(3-{2-[(3-methoxy-2-{[(4-methyl-phenyl)-sulfonyl]amino}-3-oxopropyl)amino]-2-oxoethyl}-1H-1-indolyl)propyl]-1-piperidinecarboxylate

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/S0223-5234(01)01325-3

Reference yield:

: 1912-33-0
Indole-3-acetic acid methyl ester

: 461052-63-1
benzyl 4-[3-(3-{2-[(3-methoxy-2-{[(4-methyl-phenyl)-sulfonyl]amino}-3-oxopropyl)amino]-2-oxoethyl}-1H-1-indolyl)propyl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / NaH / dimethylformamide / 20 °C

2: 80 percent / aq. LiOH / methanol / 20 °C

3: 70 percent / 4-dimethylaminopyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt / CH₂Cl₂ / 24 h / 20 °C

With dmap; lithium hydroxide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(01)01325-3

Reference yield:

: 99198-80-8
benzyl 4-(2-hydroxypropyl)-1-piperidinecarboxylate

: 461052-63-1
benzyl 4-[3-(3-{2-[(3-methoxy-2-{[(4-methyl-phenyl)-sulfonyl]amino}-3-oxopropyl)amino]-2-oxoethyl}-1H-1-indolyl)propyl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / triphenylphosphine; imidazole; iodine / toluene; acetonitrile / 3 h / 20 °C

2: 55 percent / NaH / dimethylformamide / 20 °C

3: 80 percent / aq. LiOH / methanol / 20 °C

4: 70 percent / 4-dimethylaminopyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt / CH₂Cl₂ / 24 h / 20 °C

With 1H-imidazole; dmap; lithium hydroxide; iodine; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0223-5234(01)01325-3