3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid

Base Information

Chemical Name:3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid
CAS No.:1544740-74-0
Molecular Formula:C₂₇H₂₈FN₃O₅S
Molecular Weight:525.601
Hs Code.:

3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid

Synonyms:3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid

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Chemical Property of 3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid

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Technology Process of 3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid

There total 11 articles about 3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1544740-77-3
ethyl 3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

: 1544740-74-0
3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃;

Reference yield:

: 1544740-76-2
C₁₇H₂₀FNO₄S

: 1544740-74-0
3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: manganese(IV) oxide / tetrahydrofuran / 1 h / 60 °C

2.1: titanium tetrachloride; triethylamine / dichloromethane / 16 h / -40 - 20 °C

2.2: 1 h / 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran; ethanol / 20 °C

With manganese(IV) oxide; water; titanium tetrachloride; triethylamine; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 1544740-75-1
2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzaldehyde

: 1544740-74-0
3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium tetrachloride; triethylamine / dichloromethane / 16 h / -40 - 20 °C

1.2: 1 h / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran; ethanol / 20 °C

With water; titanium tetrachloride; triethylamine; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;