ethyl 3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

Base Information

Chemical Name:ethyl 3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate
CAS No.:1544740-77-3
Molecular Formula:C₂₉H₃₂FN₃O₅S
Molecular Weight:553.655
Hs Code.:

ethyl 3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

Synonyms:ethyl 3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

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Chemical Property of ethyl 3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

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Technology Process of ethyl 3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

There total 9 articles about ethyl 3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1544739-15-2
4-amino-1,1a,6,6a-tetrahydro-3-aza-cyclopropa[a]indene-1-carboxylic acid ethyl ester

: 1544740-75-1
2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzaldehyde

: 1544740-77-3
ethyl 3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

Guidance literature:: 4-amino-1,1a,6,6a-tetrahydro-3-aza-cyclopropa[a]indene-1-carboxylic acid ethyl ester; 2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzaldehyde; With titanium tetrachloride; triethylamine; In dichloromethane; at -40 - 20 ℃; for 16h;

With sodium tris(acetoxy)borohydride; In ethanol; at 20 ℃; for 1h;

Reference yield:

: 1544740-76-2
C₁₇H₂₀FNO₄S

: 1544740-77-3
ethyl 3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: manganese(IV) oxide / tetrahydrofuran / 1 h / 60 °C

2.1: titanium tetrachloride; triethylamine / dichloromethane / 16 h / -40 - 20 °C

2.2: 1 h / 20 °C

With manganese(IV) oxide; titanium tetrachloride; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1544739-11-8
(4-allyl-5-vinyl-pyridin-2-yl)-bis-(4-methoxy-benzyl)-amine

: 1544740-77-3
ethyl 3-((2-fluoro-5-(2-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzyl)amino)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 3 h / Reflux; Inert atmosphere

2.1: dirhodium tetraacetate / dichloromethane / 0.25 h

2.2: 4 h / 20 °C / Reflux

3.1: trifluoroacetic acid / dichloromethane / 20 °C

4.1: triethylamine; titanium tetrachloride / dichloromethane / 16 h / -40 - 20 °C

4.2: 1 h / 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; dirhodium tetraacetate; titanium tetrachloride; triethylamine; trifluoroacetic acid; In dichloromethane; 1.1: |Grubbs Olefin Metathesis;