N-(4-dimethylaminobenzyl)-tert-butylamine

Base Information

• Chemical Name: N-(4-dimethylaminobenzyl)-tert-butylamine
• CAS No.: 144261-17-6
• Molecular Formula: C₁₃H₂₂N₂
• Molecular Weight: 206.331
• Mol file: 144261-17-6.mol

Synonyms:N-(4-dimethylaminobenzyl)-tert-butylamine

Chemical Property of N-(4-dimethylaminobenzyl)-tert-butylamine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-dimethylaminobenzyl)-tert-butylamine

There total 2 articles about N-(4-dimethylaminobenzyl)-tert-butylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

{4-[(Z)-tert-Butylimino-methyl]-phenyl}-dimethyl-amine (98236-03-4) → N-(4-dimethylaminobenzyl)-tert-butylamine (144261-17-6)

Guidance literature:

With bis(pentamethylcyclopentadienyl)zinc; hydrogen; 1,3-bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene; In benzene-d6; at 50 ℃; for 72h; under 75007.5 Torr; Reagent/catalyst; Temperature; Time; Pressure; Inert atmosphere;

DOI:10.1002/anie.201303968

Reference yield:

tert-butylamine (75-64-9) + 4-dimethylamino-benzaldehyde (100-10-7) → N-(4-dimethylaminobenzyl)-tert-butylamine (144261-17-6)

Guidance literature:

tert-butylamine; 4-dimethylamino-benzaldehyde; In methanol; at 80 ℃; for 12h;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 6h;

DOI:10.1021/acs.jmedchem.0c01450

Reference yield: 58.0%

3-chloro-3-oxopropanoic acid methyl ester (37517-81-0) + N-(4-dimethylaminobenzyl)-tert-butylamine (144261-17-6) → C17H26N2O3

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h;

DOI:10.1002/ejoc.201800666

upstream raw materials:

{4-[(Z)-tert-Butylimino-methyl]-phenyl}-dimethyl-amine

tert-butylamine

4-dimethylamino-benzaldehyde

Downstream raw materials:

{4-[(Z)-tert-Butylimino-methyl]-phenyl}-dimethyl-amine

4-dimethylamino-benzaldehyde

Refernces

• 1、 Flynn, Stephanie R.,Metters, Owen J.,Manners, Ian,Wass, Duncan F.. "Zirconium-Catalyzed Imine Hydrogenation via a Frustrated Lewis Pair Mechanism". . p. 847 - 850. Retrieved 2016.
• 2、 Hatnean, Jillian A.,Thomson, Jordan W.,Chase, Preston A.,Stephan, Douglas W.. "Imine hydrogenation by alkylaluminum catalysts". supporting information. p. 301 - 303. Retrieved 2014/01/06.