(+)-(2S)-Methyl 2-methyl-4-cyano-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>butanoate

Base Information

Chemical Name:(+)-(2S)-Methyl 2-methyl-4-cyano-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>butanoate
CAS No.:151074-87-2
Molecular Formula:C₁₆H₁₈N₂O₄
Molecular Weight:302.33
Hs Code.:

Synonyms:(+)-(2S)-Methyl 2-methyl-4-cyano-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>butanoate

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Chemical Property of (+)-(2S)-Methyl 2-methyl-4-cyano-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>butanoate

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Technology Process of (+)-(2S)-Methyl 2-methyl-4-cyano-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>butanoate

There total 7 articles about (+)-(2S)-Methyl 2-methyl-4-cyano-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: (2S)-Methyl 4-cyano-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>-3-butenoate

: 151074-87-2
(+)-(2S)-Methyl 2-methyl-4-cyano-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>butanoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 25 ℃; for 7h; under 1551.4 Torr;
DOI:10.1021/jo00074a016

Reference yield:

: 134627-50-2
(6S,7S)-7-<(4S)-2-Oxo-4-phenyl-1,3-oxazolidin-3-yl>-1-aza-5-oxabicyclo<4.2.0>octan-8-one

: 151074-87-2
(+)-(2S)-Methyl 2-methyl-4-cyano-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>butanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / KHMDS / toluene; tetrahydrofuran; dimethylformamide / 1.) -78 deg C, 1 h, 2.) -78 deg C, 15 min

2: HCl / methanol / 24 h / 25 °C

3: 50 percent / 1 N HCl / tetrahydrofuran / 48 h / 25 °C

4: 95 percent / tetrahydrofuran / 72 h / 25 °C

5: 80 percent / H₂ / 10percent Pd/C / methanol / 7 h / 25 °C / 1551.4 Torr

With hydrogenchloride; hydrogen; potassium hexamethylsilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00074a016

Reference yield:

: (6S,7S)-7-((S)-2-Hydroxy-1-phenyl-ethylamino)-5-oxa-1-aza-bicyclo[4.2.0]octan-8-one

: 151074-87-2
(+)-(2S)-Methyl 2-methyl-4-cyano-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>butanoate

Guidance literature:: Multi-step reaction with 6 steps

1: i-Pr₂NEt / CH₂Cl₂ / 0.75 h / 0 °C

2: 80 percent / KHMDS / toluene; tetrahydrofuran; dimethylformamide / 1.) -78 deg C, 1 h, 2.) -78 deg C, 15 min

3: HCl / methanol / 24 h / 25 °C

4: 50 percent / 1 N HCl / tetrahydrofuran / 48 h / 25 °C

5: 95 percent / tetrahydrofuran / 72 h / 25 °C

6: 80 percent / H₂ / 10percent Pd/C / methanol / 7 h / 25 °C / 1551.4 Torr

With hydrogenchloride; hydrogen; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00074a016