tert-butyl 1,2-dihydro-5-(benzyloxy)-1-(chloromethyl)-6-(carboxylic acid)benzo[e]indole-3-carboxylate

Base Information

• Chemical Name: tert-butyl 1,2-dihydro-5-(benzyloxy)-1-(chloromethyl)-6-(carboxylic acid)benzo[e]indole-3-carboxylate
• CAS No.: 1433974-78-7
• Molecular Formula: C₂₆H₂₆ClNO₅
• Molecular Weight: 467.949
• Mol file: 1433974-78-7.mol

Synonyms:tert-butyl 1,2-dihydro-5-(benzyloxy)-1-(chloromethyl)-6-(carboxylic acid)benzo[e]indole-3-carboxylate

Chemical Property of tert-butyl 1,2-dihydro-5-(benzyloxy)-1-(chloromethyl)-6-(carboxylic acid)benzo[e]indole-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 1,2-dihydro-5-(benzyloxy)-1-(chloromethyl)-6-(carboxylic acid)benzo[e]indole-3-carboxylate

There total 1 articles about tert-butyl 1,2-dihydro-5-(benzyloxy)-1-(chloromethyl)-6-(carboxylic acid)benzo[e]indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

carbon dioxide (124-38-9,18923-20-1) + tert-butyl 1,2-dihydro-5-(benzyloxy)-6-bromo-1-(chloromethyl)-1H-benzo[e]indole-3(2H)-carboxylate (1381964-05-1) → tert-butyl 1,2-dihydro-5-(benzyloxy)-1-(chloromethyl)-6-(carboxylic acid)benzo[e]indole-3-carboxylate (1433974-78-7)

Guidance literature:

tert-butyl 1,2-dihydro-5-(benzyloxy)-6-bromo-1-(chloromethyl)-1H-benzo[e]indole-3(2H)-carboxylate; With phenyllithium; In tetrahydrofuran; at -78 ℃; for 0.75h; Inert atmosphere;

carbon dioxide; In tetrahydrofuran; at -78 - 0 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; Inert atmosphere;

DOI:10.1021/jm400413r

Reference yield: 93.0%

tert-butyl 1,2-dihydro-5-(benzyloxy)-1-(chloromethyl)-6-(carboxylic acid)benzo[e]indole-3-carboxylate (1433974-78-7) → C26H27ClN2O5

Guidance literature:

tert-butyl 1,2-dihydro-5-(benzyloxy)-1-(chloromethyl)-6-(carboxylic acid)benzo[e]indole-3-carboxylate; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In tetrahydrofuran; for 2h; Inert atmosphere;

With hydroxylamine hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; for 6h; Inert atmosphere;

DOI:10.1021/jm400413r

Reference yield:

tert-butyl 1,2-dihydro-5-(benzyloxy)-1-(chloromethyl)-6-(carboxylic acid)benzo[e]indole-3-carboxylate (1433974-78-7) + N-methylhydroxyamine hydrochloride (4229-44-1) → C27H29ClN2O5 (1433974-79-8)

Guidance literature:

tert-butyl 1,2-dihydro-5-(benzyloxy)-1-(chloromethyl)-6-(carboxylic acid)benzo[e]indole-3-carboxylate; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 1h;

N-methylhydroxyamine hydrochloride; With triethylamine; In tetrahydrofuran; dichloromethane; water; at 0 - 20 ℃; for 1h;

upstream raw materials:

carbon dioxide

tert-butyl 1,2-dihydro-5-(benzyloxy)-6-bromo-1-(chloromethyl)-1H-benzo[e]indole-3(2H)-carboxylate

Downstream raw materials:

C₂₇H₂₉ClN₂O₅