Benzoic acid (R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-2-methyl-propyl ester

Base Information

• Chemical Name: Benzoic acid (R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-2-methyl-propyl ester
• CAS No.: 97971-43-2
• Molecular Formula: C₁₆H₂₂O₅
• Molecular Weight: 294.348
• Mol file: 97971-43-2.mol

Synonyms:Benzoic acid (R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-2-methyl-propyl ester

Chemical Property of Benzoic acid (R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-2-methyl-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid (R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-2-methyl-propyl ester

There total 5 articles about Benzoic acid (R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-2-methyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzoyl chloride (98-88-4) + (R)-1-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-methyl-propane-1,2-diol (97971-42-1) → Benzoic acid (R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-2-methyl-propyl ester (97971-43-2)

Guidance literature:

With pyridine; for 0.5h; Ambient temperature;

DOI:10.1248/cpb.42.1328

Reference yield:

methyl (2R,3S)-3,4-O-isopropylidene-2,3,4-trihydroxybutanoate (92973-40-5) → Benzoic acid (R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-2-methyl-propyl ester (97971-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / diethyl ether / 0.5 h / Heating

2: 97 percent / pyridine / 0.5 h / Ambient temperature

With pyridine; In diethyl ether;

DOI:10.1248/cpb.42.1328

Reference yield:

Kalium-<4S-(R*,S*)>-α-hydroxy-2,2-dimethyl-1,3-dioxolan-4-acetat (93367-08-9) → Benzoic acid (R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-2-methyl-propyl ester (97971-43-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 63 percent / HCl / methanol / -78 °C

With hydrogenchloride; In methanol;

DOI:10.1248/cpb.33.1313

upstream raw materials:

(R)-1-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-methyl-propane-1,2-diol

benzoyl chloride

methyl (2R,3S)-3,4-O-isopropylidene-2,3,4-trihydroxybutanoate

Kalium-<4S-(R*,S*)>-α-hydroxy-2,2-dimethyl-1,3-dioxolan-4-acetat

Downstream raw materials:

Ethyl 4(R)-(tert-Butyldiphenylsiloxy)-5,6-epoxy-5(R)-methyl-but-2(E)-enoate

Ethyl 4(R)-(tert-Butyldiphenylsiloxy)-5,6-epoxy-5(S)-methyl-but-2(E)-enoate

4,5-Isopropylidenedioxy-3-(tert-butyldiphenylsiloxy)-2-methylpent-1-ene

Ethyl 4-(tert-Butyldiphenylsiloxy)-5-methyl-hexa-2(E),5-dienoate