2-<2-<2-(Benzyloxycarboxamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionsaeure

Base Information

• Chemical Name: 2-<2-<2-(Benzyloxycarboxamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionsaeure
• CAS No.: 4512-41-8
• Molecular Formula: C₂₀H₂₉N₃O₆
• Molecular Weight: 407.467
• Mol file: 4512-41-8.mol

Synonyms:2-<2-<2-(Benzyloxycarboxamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionsaeure

Chemical Property of 2-<2-<2-(Benzyloxycarboxamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionsaeure

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<2-<2-(Benzyloxycarboxamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionsaeure

There total 9 articles about 2-<2-<2-(Benzyloxycarboxamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionsaeure which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-<2-<2-(Benzyloxycarboxamido)-2-methylpropionamido>-2-methylpropionamido>-N,N,2-trimethylpropionamid (111492-32-1) → 2-<2-<2-(Benzyloxycarboxamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionsaeure (4512-41-8)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/hlca.201100116

Reference yield: 85.0%

N-[benzyloxycarbonyl]-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide (1312775-18-0) → 2-<2-<2-(Benzyloxycarboxamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionsaeure (4512-41-8)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1002/hlca.201100116

Reference yield:

Z-Aib-OH (15030-72-5) → 2-<2-<2-(Benzyloxycarboxamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionsaeure (4512-41-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / acetonitrile / Ambient temperature

2: 96 percent / HCl / acetonitrile; H₂O

3: 93 percent / acetonitrile

4: 92 percent / HCl / acetonitrile; H₂O

With hydrogenchloride; In water; acetonitrile;

DOI:10.1002/hlca.19870700112

upstream raw materials:

2-<2-<2-(Benzyloxycarboxamido)-2-methylpropionamido>-2-methylpropionamido>-N,N,2-trimethylpropionamid

Z-Aib-OH

2-<2-(Benzyloxycarboxamido)-2-methylpropionamido>-2-methylpropionsaeure

benzyl chloroformate

Downstream raw materials:

2-<2-<2-<2-(Benzyloxycarboxamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionamido>-N,N,2-trimethylpropionamid

N-[benzyloxycarbonyl]-2-methylalanyl-2-methylalanyl-2-methylalanyl-L-prolyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide

N-[benzyloxycarbonyl]-2-methylalanyl-2-methylalanyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide

N-[benzyloxycarbonyl]-2-methylalanyl-2-methylalanyl-2-methylalanyl-2-methylalanyl-2-methylalanyl-2-methylalanine-N-methyl-N-phenylamide