1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid methylamide

Base Information

Chemical Name:1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid methylamide
CAS No.:1401102-80-4
Molecular Formula:C₂₁H₁₆Cl₄F₃N₃O₂
Molecular Weight:541.184
Hs Code.:

Synonyms:1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid methylamide

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Chemical Property of 1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid methylamide

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Technology Process of 1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid methylamide

There total 5 articles about 1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1401102-98-4
1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid

: 74-89-5
methylamine

: 1401102-80-4
1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid methylamide

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃; for 20h;

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1401102-80-4
1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dimethyl sulfoxide / 24 h / 20 - 100 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 2 h / 0 - 20 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium acetate / water; methanol / 3 h / 0 - 20 °C

4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.5 h / 20 - 45 °C

4.2: 18 h / 20 °C / Inert atmosphere

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 18 h / 20 °C

5.2: pH ~ 5

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; HATU / N,N-dimethyl-formamide; tetrahydrofuran / 20 h / 0 - 20 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; water; sodium acetate; potassium carbonate; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1401102-97-3
1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid methyl ester

: 1401102-80-4
1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran; methanol / 18 h / 20 °C

1.2: pH ~ 5

2.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; HATU / N,N-dimethyl-formamide; tetrahydrofuran / 20 h / 0 - 20 °C

With water; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;