C₁₈H₈ClF₂NO₃

Base Information

Chemical Name:C₁₈H₈ClF₂NO₃
CAS No.:1231209-20-3
Molecular Formula:C₁₈H₈ClF₂NO₃
Molecular Weight:359.716
Hs Code.:

C<sub>18</sub>H<sub>8</sub>ClF<sub>2</sub>NO<sub>3</sub>

Synonyms:C₁₈H₈ClF₂NO₃

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Chemical Property of C₁₈H₈ClF₂NO₃

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Technology Process of C₁₈H₈ClF₂NO₃

There total 3 articles about C₁₈H₈ClF₂NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1231209-02-1
Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-cyano-5-fluorophenyl)furan-2-carboxylate

: 1231209-20-3
C₁₈H₈ClF₂NO₃

Guidance literature:: Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-cyano-5-fluorophenyl)furan-2-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 179898-34-1
3-bromo-5-fluorobenzonitrile

: 1231209-20-3
C₁₈H₈ClF₂NO₃

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; dimethyl sulfoxide / 90 °C / Inert atmosphere

2: caesium carbonate; XPhos / palladium diacetate / 1,2-dimethoxyethane / 48 h / 50 °C / Inert atmosphere

3: water; lithium hydroxide / tetrahydrofuran / 20 °C

With water; potassium acetate; caesium carbonate; lithium hydroxide; XPhos; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dimethyl sulfoxide; 1: Suzuki Coupling;

Reference yield:

: 935685-88-4
3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenecarbonitrile

: 1231209-20-3
C₁₈H₈ClF₂NO₃

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; XPhos / palladium diacetate / 1,2-dimethoxyethane / 48 h / 50 °C / Inert atmosphere

2: water; lithium hydroxide / tetrahydrofuran / 20 °C

With water; caesium carbonate; lithium hydroxide; XPhos; palladium diacetate; In tetrahydrofuran; 1,2-dimethoxyethane;