METHYL 1-(2-METHOXYPHENYL)-5-OXOPYRROLIDINE-3-CARBOXYLATE

Base Information

Chemical Name:METHYL 1-(2-METHOXYPHENYL)-5-OXOPYRROLIDINE-3-CARBOXYLATE
CAS No.:910443-46-8
Molecular Formula:C₁₃H₁₅NO₄
Molecular Weight:249.266
Hs Code.:
Mol file:910443-46-8.mol

Synonyms:1-(2-methoxyphenyl)-5-oxopyrrolidine-3-carboxylic acid methyl ester

Suppliers and Price of METHYL 1-(2-METHOXYPHENYL)-5-OXOPYRROLIDINE-3-CARBOXYLATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
METHYL 1-(2-METHOXYPHENYL)-5-OXOPYRROLIDINE-3-CARBOXYLATE 95.00%
5MG
$ 501.64

Total 3 raw suppliers

Chemical Property of METHYL 1-(2-METHOXYPHENYL)-5-OXOPYRROLIDINE-3-CARBOXYLATE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

METHYL 1-(2-METHOXYPHENYL)-5-OXOPYRROLIDINE-3-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of METHYL 1-(2-METHOXYPHENYL)-5-OXOPYRROLIDINE-3-CARBOXYLATE

There total 1 articles about METHYL 1-(2-METHOXYPHENYL)-5-OXOPYRROLIDINE-3-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 67-56-1
methanol

: 39629-90-8
1-(2-methoxyphenyl)-5-oxopyrrolidine-3-carboxylic acid

: 910443-46-8
1-(2-methoxyphenyl)-5-oxopyrrolidine-3-carboxylic acid methyl ester

Guidance literature:: methanol; With thionyl chloride; at -5 ℃; for 1h;

1-(2-methoxyphenyl)-5-oxopyrrolidine-3-carboxylic acid; at -5 - 30 ℃;
DOI:10.1016/j.tet.2006.02.030

Reference yield:

: 910443-46-8
1-(2-methoxyphenyl)-5-oxopyrrolidine-3-carboxylic acid methyl ester

: 1-{3-[6-(2-methoxyphenyl)-3,6-diazabicyclo[3.2.1]oct-3-yl]propyl}piperidine-2,6-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: 91 percent / Lawesson's reagent / tetrahydrofuran / 25 - 30 °C

2.1: 90 percent / 2 h / 25 - 30 °C

3.1: 45 percent / triethylamine / dimethylformamide / 12 h / 25 - 30 °C

4.1: ammonium formate / Pd-C / methanol / 10 h / Heating

4.2: 70 percent / ammonia / CHCl₃ / 0.5 h / 25 - 30 °C

5.1: 57 percent / lithium aluminum hydride / tetrahydrofuran / 18 h / Heating

6.1: 78 percent / K₂CO₃; KI / dimethylformamide / 18 h / 60 - 70 °C

With Lawessons reagent; lithium aluminium tetrahydride; ammonium formate; potassium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.02.030

Reference yield:

: 910443-46-8
1-(2-methoxyphenyl)-5-oxopyrrolidine-3-carboxylic acid methyl ester

: 1-{3-[6-(2-methoxyphenyl)-3,6-diazabicyclo[3.2.1]oct-3-yl]propyl}-4,4-dimethyl-piperidine-2,6-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: 91 percent / Lawesson's reagent / tetrahydrofuran / 25 - 30 °C

2.1: 90 percent / 2 h / 25 - 30 °C

3.1: 45 percent / triethylamine / dimethylformamide / 12 h / 25 - 30 °C

4.1: ammonium formate / Pd-C / methanol / 10 h / Heating

4.2: 70 percent / ammonia / CHCl₃ / 0.5 h / 25 - 30 °C

5.1: 57 percent / lithium aluminum hydride / tetrahydrofuran / 18 h / Heating

6.1: 46 percent / K₂CO₃; KI / dimethylformamide / 18 h / 60 - 70 °C

With Lawessons reagent; lithium aluminium tetrahydride; ammonium formate; potassium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.02.030