4-(2-(3,5-dimethoxyphenylethyl)-5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-6-yl)picolinonitrile

Base Information

Chemical Name:4-(2-(3,5-dimethoxyphenylethyl)-5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-6-yl)picolinonitrile
CAS No.:1560796-16-8
Molecular Formula:C₂₈H₂₃N₅O₄S
Molecular Weight:525.588
Hs Code.:

Synonyms:4-(2-(3,5-dimethoxyphenylethyl)-5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-6-yl)picolinonitrile

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Chemical Property of 4-(2-(3,5-dimethoxyphenylethyl)-5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-6-yl)picolinonitrile

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Technology Process of 4-(2-(3,5-dimethoxyphenylethyl)-5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-6-yl)picolinonitrile

There total 6 articles about 4-(2-(3,5-dimethoxyphenylethyl)-5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-6-yl)picolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 741709-62-6
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinecarbonitrile

: 1560795-89-2
6-bromo-2-[2-(3,5-dimethoxyphenyl)ethyl]-5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine

: 1560796-16-8
4-(2-(3,5-dimethoxyphenylethyl)-5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-6-yl)picolinonitrile

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In water; acetonitrile; at 100 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1560795-84-7
2-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine

: 1560796-16-8
4-(2-(3,5-dimethoxyphenylethyl)-5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-6-yl)picolinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium on activated carbon; hydrogen / tetrahydrofuran; methanol / 24 h / 20 °C / 2327.23 Torr

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / 78 °C

2.2: 1 h

3.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; acetonitrile / 3 h / 100 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated carbon; hydrogen; sodium carbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol; water; acetonitrile; 3.1: |Suzuki Coupling;

Reference yield:

: 5-(benzenesulfonyl)-2-bromo-5H-pyrrolo[2,3-b]pyrazine

: 1560796-16-8
4-(2-(3,5-dimethoxyphenylethyl)-5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-6-yl)picolinonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 88 °C

2.1: palladium on activated carbon; hydrogen / tetrahydrofuran; methanol / 24 h / 20 °C / 2327.23 Torr

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / 78 °C

3.2: 1 h

4.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; acetonitrile / 3 h / 100 °C / Inert atmosphere

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated carbon; hydrogen; sodium carbonate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile; 4.1: |Suzuki Coupling;