(S)-2-(1-aminoethyl)-5-chloro-3-phenylpyrrolo[2,1-f][1,2,4]triazine-4(3H)-one

Base Information

Chemical Name:(S)-2-(1-aminoethyl)-5-chloro-3-phenylpyrrolo[2,1-f][1,2,4]triazine-4(3H)-one
CAS No.:1466566-00-6
Molecular Formula:C₁₄H₁₃ClN₄O
Molecular Weight:288.736
Hs Code.:

Synonyms:(S)-2-(1-aminoethyl)-5-chloro-3-phenylpyrrolo[2,1-f][1,2,4]triazine-4(3H)-one

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Chemical Property of (S)-2-(1-aminoethyl)-5-chloro-3-phenylpyrrolo[2,1-f][1,2,4]triazine-4(3H)-one

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Technology Process of (S)-2-(1-aminoethyl)-5-chloro-3-phenylpyrrolo[2,1-f][1,2,4]triazine-4(3H)-one

There total 8 articles about (S)-2-(1-aminoethyl)-5-chloro-3-phenylpyrrolo[2,1-f][1,2,4]triazine-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1466566-00-6
(S)-2-(1-aminoethyl)-5-chloro-3-phenylpyrrolo[2,1-f][1,2,4]triazine-4(3H)-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 0.5h;

Reference yield:

: tert-butyl (S)-(1-(5-chloro-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-2-yl)ethyl)carbamate

: 1466566-00-6
(S)-2-(1-aminoethyl)-5-chloro-3-phenylpyrrolo[2,1-f][1,2,4]triazine-4(3H)-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 4h;
DOI:10.3762/bjoc.12.168

Reference yield:

: 1466565-96-7
3-chloro-N-phenyl-1H-pyrrole-2-carboxamide

: 1466566-00-6
(S)-2-(1-aminoethyl)-5-chloro-3-phenylpyrrolo[2,1-f][1,2,4]triazine-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; ammonium chloride; sodium hypochlorite; Aliquat 336; ammonium hydroxide / water; tert-butyl methyl ether; diethyl ether / 0 - 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 17 h / 20 °C

3: triphenylphosphine; bromine; triethylamine / dichloromethane / 0.33 h / 0 - 20 °C

4: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C

With ammonium hydroxide; sodium hypochlorite; bromine; Aliquat 336; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; tert-butyl methyl ether; water;
DOI:10.3762/bjoc.12.168