1466565-96-7

Upstream product

• 872-32-2 2-methyl-1H-pyrroline 
• 226409-94-5 4,4-dichloro-5-(trichloromethyl)-3,4-dihydro-2H-pyrrole 
• 226410-00-0 3-chloro-1H-pyrrole-2-carboxylic acid methyl ester 
• 1053658-09-5 3-chloro-1H-pyrrole-2-carboxylic acid 
• 62-53-3 aniline 
• 721450-11-9 3-chloro-1H-pyrrole-2-carbonyl chloride 

Downstream Products

• 1403941-86-5 1-amino-3-chloro-N-phenyl-1H-pyrrole-2-carboxamide 
• 1466565-97-8 tert-butyl (S)-(1-((3-chloro-2-(phenylcarbamoyl)-1H-pyrrole-1-yl)amino)-1-oxopropane-2-yl)carbamate 
• 1466565-98-9 C₁₉H₂₁ClN₄O₃ 
• 1466565-99-0 C₁₄H₁₃ClN₄O 
• 1548332-55-3 (S)-2-(1-(9H-purin-6-yl)pyrrolidin-2-yl)-5-chloro-3-phenylpyrrolo[2,1-f][1, 2,4]triazin-4(3H)-one 
• 1548942-78-4 (S)-5-chloro-3-phenyl-2-(pyrrolidine-2-yl)pyrrolo[2,1-f][1,2,4]triazine-4(3H)-one 
• 1466566-00-6 (S)-2-(1-aminoethyl)-5-chloro-3-phenylpyrrolo[2,1-f][1,2,4]triazine-4(3H)-one 

Relevant academic research and scientific papers

HETEROARYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSTION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH PI3 KINASES, CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to a heteroaryl derivative or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition for preventing or treating diseases associated with PI3 kinases, containing the same as an active ingredient. The heteroaryl derivative according to the present invention has an excellent effect of selectively inhibiting PI3 kinases, thereby being useful in preventing or treating PI3 kinase diseases such as: cancers, autoimmune diseases, and respiratory diseases.

Pyrimido oxazine derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and pharmaceutical composition for use in preventing or treating PI3 kinase related diseases

The present invention relates to pyrimido oxazine derivatives or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition comprising the same as an effective component for preventing or treating PI3 kinase-related diseases. The pyrimido oxazine derivatives according to the present invention have excellent selective inhibitory effects on PI3 kinase, and thus may be beneficially used in preventing or treating PI3 kinase-related diseases such as the following: cancers including blood cancer, ovarian cancer, cervical cancer, breast cancer, large intestine cancer, liver cancer, stomach cancer, pancreatic cancer, colon cancer, periotoneal cancer, skin cancer, bladder cancer, prostate cancer, lung cancer, osteosarcoma, fibrous tumor, and brain tumor; autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, hyperthyroidism, myasthenia gravis, Crohnandprime;s disease, ankylosing spondylitis, psoriasis, pernicious anemia, and Sjogrenandprime;s syndrome; and respiratory diseases including chronic obstructive pulmonary disease (COPD), rhinitis, asthma, chronic bronchitis, chronic pulmonary inflammatory diseases, silicosis, pulmonary sarcoidosis, pleuritis, alveolitis, vasculitis, emphysema, pneumonia, and bronchiectasis.COPYRIGHT KIPO 2017

Synthesis of pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones: Rearrangement of pyrrolo[1,2-d][1,3,4]oxadiazines and regioselective intramolecular cyclization of 1,2-biscarbamoyl-substituted 1H-pyrroles

Pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones 12 have been easily prepared via nucleophile-induced rearrangement of pyrrolooxadiazines 11 and regioselective intramolecular cyclization of 1,2-biscarbamoyl-substituted 1H-pyrroles 10. In this work, we demonstrated

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.