6-HYDROXYNICOTINONITRILE

Base Information

• Chemical Name: 6-HYDROXYNICOTINONITRILE
• CAS No.: 95891-30-8
• Molecular Formula: C₆H₄N₂O
• Molecular Weight: 120.111
• Mol file: 95891-30-8.mol

Synonyms:6-HYDROXYNICOTINONITRILE

Chemical Property of 6-HYDROXYNICOTINONITRILE

Chemical Property:

• PSA: 56.91000
• LogP: 0.65888
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-Hydroxynicotinonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-HYDROXYNICOTINONITRILE

There total 6 articles about 6-HYDROXYNICOTINONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

pyridine-3-carbonitrile (100-54-9,121697-66-3,1232169-17-3,68271-95-4) → 6-hydroxy-3-pyridinecarbonitrile (94805-52-4,95891-30-8)

Guidance literature:

Microbiological reaction;

DOI:10.1246/bcsj.73.1227

Reference yield: 78.1%

6-aminonicotinonitrile (4214-73-7) → 6-hydroxy-3-pyridinecarbonitrile (94805-52-4,95891-30-8)

Guidance literature:

DOI:10.1271/bbb.59.572

Reference yield:

5-bromo-2-pyridylamine (1072-97-5) → 6-hydroxy-3-pyridinecarbonitrile (94805-52-4,95891-30-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 4 h / Inert atmosphere; Schlenk technique; Reflux

2: sulfuric acid; sodium nitrite / 2 h / 0 °C / Inert atmosphere; Schlenk technique

With sulfuric acid; sodium nitrite; In N,N-dimethyl-formamide;

DOI:10.1016/j.jorganchem.2017.05.018

upstream raw materials:

5-amino-2-hydroxypyridine

potassium cyanide

6-aminonicotinonitrile

6-ethoxy-nicotinonitrile

Downstream raw materials:

6-chloro-5-nitro-3-pyridinecarbonitrile