N-[4-(4-{4-[bis(2-chloroethyl)amino]phenyl}butanoyloxy)phenyl]-3,4,6-tri-O-benzyl-2-deoxy-2-fluoro-β-D-glucopyranosylamine

Base Information

Chemical Name:N-[4-(4-{4-[bis(2-chloroethyl)amino]phenyl}butanoyloxy)phenyl]-3,4,6-tri-O-benzyl-2-deoxy-2-fluoro-β-D-glucopyranosylamine
CAS No.:1001406-98-9
Molecular Formula:C₄₇H₅₁Cl₂FN₂O₆
Molecular Weight:829.836
Hs Code.:

Synonyms:N-[4-(4-{4-[bis(2-chloroethyl)amino]phenyl}butanoyloxy)phenyl]-3,4,6-tri-O-benzyl-2-deoxy-2-fluoro-β-D-glucopyranosylamine

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Chemical Property of N-[4-(4-{4-[bis(2-chloroethyl)amino]phenyl}butanoyloxy)phenyl]-3,4,6-tri-O-benzyl-2-deoxy-2-fluoro-β-D-glucopyranosylamine

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Technology Process of N-[4-(4-{4-[bis(2-chloroethyl)amino]phenyl}butanoyloxy)phenyl]-3,4,6-tri-O-benzyl-2-deoxy-2-fluoro-β-D-glucopyranosylamine

There total 6 articles about N-[4-(4-{4-[bis(2-chloroethyl)amino]phenyl}butanoyloxy)phenyl]-3,4,6-tri-O-benzyl-2-deoxy-2-fluoro-β-D-glucopyranosylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1001406-99-0
4-{4-[bis(2-chloroethyl)amino]phenyl}butyric acid 4-aminophenyl ester

: 186419-71-6
3,4,6-tri-O-benzyl-2-deoxy-2-fluoro-α-D-glucopyranosyl bromide

: 1001406-98-9
N-[4-(4-{4-[bis(2-chloroethyl)amino]phenyl}butanoyloxy)phenyl]-3,4,6-tri-O-benzyl-2-deoxy-2-fluoro-β-D-glucopyranosylamine

Guidance literature:: With silver(l) oxide; In acetonitrile; at 20 ℃; for 20h;
DOI:10.1016/j.bmc.2008.03.038

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 1001406-98-9
N-[4-(4-{4-[bis(2-chloroethyl)amino]phenyl}butanoyloxy)phenyl]-3,4,6-tri-O-benzyl-2-deoxy-2-fluoro-β-D-glucopyranosylamine

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 24 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 24 h / 760.05 Torr

3: silver(l) oxide / acetonitrile / 20 h / 20 °C

With dmap; hydrogen; dicyclohexyl-carbodiimide; silver(l) oxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 187218-20-8
4-{4-[bis(2-chloroethyl)amino]phenyl}butyric acid 4-nitrophenyl ester

: 1001406-98-9
N-[4-(4-{4-[bis(2-chloroethyl)amino]phenyl}butanoyloxy)phenyl]-3,4,6-tri-O-benzyl-2-deoxy-2-fluoro-β-D-glucopyranosylamine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 24 h / 760.05 Torr

2: silver(l) oxide / acetonitrile / 20 h / 20 °C

With hydrogen; silver(l) oxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; acetonitrile;