4-{4-[bis(2-chloroethyl)amino]phenyl}butyric acid 4-aminophenyl ester

Base Information

• Chemical Name: 4-{4-[bis(2-chloroethyl)amino]phenyl}butyric acid 4-aminophenyl ester
• CAS No.: 1001406-99-0
• Molecular Formula: C₂₀H₂₄Cl₂N₂O₂
• Molecular Weight: 395.329

Synonyms:4-{4-[bis(2-chloroethyl)amino]phenyl}butyric acid 4-aminophenyl ester

Chemical Property of 4-{4-[bis(2-chloroethyl)amino]phenyl}butyric acid 4-aminophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{4-[bis(2-chloroethyl)amino]phenyl}butyric acid 4-aminophenyl ester

There total 3 articles about 4-{4-[bis(2-chloroethyl)amino]phenyl}butyric acid 4-aminophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-{4-[bis(2-chloroethyl)amino]phenyl}butyric acid 4-nitrophenyl ester (187218-20-8) → 4-{4-[bis(2-chloroethyl)amino]phenyl}butyric acid 4-aminophenyl ester (1001406-99-0)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 20h;

DOI:10.1016/j.bmc.2017.08.043

Reference yield:

chlorambucil (305-03-3) → 4-{4-[bis(2-chloroethyl)amino]phenyl}butyric acid 4-aminophenyl ester (1001406-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 24 h / 20 °C

2: hydrogen; palladium on activated charcoal / ethanol / 20 h / 20 °C

With dmap; palladium on activated charcoal; hydrogen; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;

DOI:10.1016/j.bmc.2017.08.043

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → 4-{4-[bis(2-chloroethyl)amino]phenyl}butyric acid 4-aminophenyl ester (1001406-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 24 h / 20 °C

2: hydrogen; palladium on activated charcoal / ethanol / 20 h / 20 °C

With dmap; palladium on activated charcoal; hydrogen; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;

DOI:10.1016/j.bmc.2017.08.043

upstream raw materials:

4-{4-[bis(2-chloroethyl)amino]phenyl}butyric acid 4-nitrophenyl ester

chlorambucil

4-nitro-phenol

Downstream raw materials:

N-[4-(4-{4-[bis(2-chloroethyl)amino]phenyl}butanoyloxy)phenyl]-3,4,6-tri-O-benzyl-2-deoxy-2-fluoro-β-D-glucopyranosylamine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1001406-99-0 4-{4-[bis(2-chloroethyl)amino]phenyl}butyric acid 4-aminophenyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send