(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(6'-methyl-2'-(4-methylbenzyloxy)-cyclohex-2'-en-4'-one)

Base Information

Chemical Name:(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(6'-methyl-2'-(4-methylbenzyloxy)-cyclohex-2'-en-4'-one)
CAS No.:1158186-23-2
Molecular Formula:C₂₄H₂₃ClO₆
Molecular Weight:442.896
Hs Code.:

Synonyms:(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(6'-methyl-2'-(4-methylbenzyloxy)-cyclohex-2'-en-4'-one)

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Chemical Property of (2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(6'-methyl-2'-(4-methylbenzyloxy)-cyclohex-2'-en-4'-one)

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Technology Process of (2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(6'-methyl-2'-(4-methylbenzyloxy)-cyclohex-2'-en-4'-one)

There total 4 articles about (2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(6'-methyl-2'-(4-methylbenzyloxy)-cyclohex-2'-en-4'-one) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 26881-56-1
(6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(2'-chloro-6'-methyl-cyclohex-2'-en-4'-one)

: 589-18-4
4-Methylbenzyl alcohol

: 1158186-23-2
(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(6'-methyl-2'-(4-methylbenzyloxy)-cyclohex-2'-en-4'-one)

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; at 100 ℃; for 12h;
DOI:10.1021/jm801517j

Reference yield:

: 126-07-8
griseofulvin

: 1158186-23-2
(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(6'-methyl-2'-(4-methylbenzyloxy)-cyclohex-2'-en-4'-one)

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid; acetic acid

2: lithium chloride; trichlorophosphate / 1,4-dioxane / 0.5 h / 100 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene

With sulfuric acid; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; trichlorophosphate; In 1,4-dioxane;
DOI:10.1021/jm200835c

Reference yield:

: 1158186-19-6
griseofulvic acid

: 1158186-23-2
(2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(6'-methyl-2'-(4-methylbenzyloxy)-cyclohex-2'-en-4'-one)

Guidance literature:: Multi-step reaction with 2 steps

1: lithium chloride; trichlorophosphate / 1,4-dioxane / 0.5 h / 100 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene

With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; trichlorophosphate; In 1,4-dioxane;
DOI:10.1021/jm200835c