toluene-4-sulfonic acid 4-tert-butoxycarbonylaminobutyl ester

Base Information

• Chemical Name: toluene-4-sulfonic acid 4-tert-butoxycarbonylaminobutyl ester
• CAS No.: 180851-50-7
• Molecular Formula: C₁₆H₂₅NO₅S
• Molecular Weight: 343.444
• Mol file: 180851-50-7.mol

Synonyms:toluene-4-sulfonic acid 4-tert-butoxycarbonylaminobutyl ester

Chemical Property of toluene-4-sulfonic acid 4-tert-butoxycarbonylaminobutyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Toluene-4-sulfonicacid4-tert-butoxy-carbonylamino-butylester 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of toluene-4-sulfonic acid 4-tert-butoxycarbonylaminobutyl ester

There total 4 articles about toluene-4-sulfonic acid 4-tert-butoxycarbonylaminobutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.17%

(4-hydroxybutyl)carbamic acid tert-butyl ester (75178-87-9) + p-toluenesulfonyl chloride (98-59-9) → toluene-4-sulfonic acid 4-tert-butoxycarbonylaminobutyl ester (180851-50-7)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 7h;

DOI:10.1021/jm060126s

Reference yield: 70.0%

→ toluene-4-sulfonic acid 4-tert-butoxycarbonylaminobutyl ester (180851-50-7)

Guidance literature:

With dmap; triethylamine;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → toluene-4-sulfonic acid 4-tert-butoxycarbonylaminobutyl ester (180851-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / Et₃N / CH₂Cl₂ / 6 h / 20 °C

2: 82 percent / Et₃N; DMAP / CH₂Cl₂ / 7 h / 0 - 20 °C

With dmap; triethylamine; In dichloromethane;

DOI:10.1021/jm060126s

upstream raw materials:

(4-hydroxybutyl)carbamic acid tert-butyl ester

p-toluenesulfonyl chloride

di-tert-butyl dicarbonate

Downstream raw materials:

N⁵-Benzyl-N¹,N⁹-bis[t-butoxycarbonyl]homospermidine

{4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}carbamic acid tert-butyl ester

1,1-dimethylethyl (4-{4-[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]hexahydro-1H-azepin-1-yl}butyl)carbamate

tert-butyl (4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)carbamate