75178-87-9

Basic information

• Product Name: TERT-BUTYL N-(4-HYDROXYBUTYL)CARBAMATE
• Synonyms: N-(4-HYDROXYBUTYL)CARBAMIC ACID TERT-BUTYL ESTER;N-BOC-4-AMINOBUTANOL;N-T-BUTOXYCARBONYL-4-AMINO-1-BUTANOL;N-T-BUTOXYCARBONYL-DELTA-AMINO-N-BUTYL ALCOHOL;TERT-BUTYL N-(4-HYDROXYBUTYL)CARBAMATE;BOC-NH-(CH2)4-OH;BOC-ABU(4)-OL;BOC-4-AMINOBUTANOL
• CAS NO: 75178-87-9
• Molecular Formula: C₉H₁₉NO₃
• Molecular Weight: 189.25
• Product Categories: Aliphatics;Amino Acids & Derivatives
• Mol File: 75178-87-9.mol
• Article Data: 88

Chemical Properties

• Melting Point: 29 °C
• Boiling Point: 302.7°C at 760 mmHg
• Flash Point: 29 °C
• Appearance: Colorless to yellow/Liquid or Low Melting Solid
• Density: 1.02 g/mL at 20 °C(lit.)
• Vapor Pressure: 9.39E-05mmHg at 25°C
• Refractive Index: n20/D 1.456
• Storage Temp.: 2-8°C
• PKA: 12.80±0.46(Predicted)
• BRN: 3603307
• CAS DataBase Reference: TERT-BUTYL N-(4-HYDROXYBUTYL)CARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL N-(4-HYDROXYBUTYL)CARBAMATE(75178-87-9)
• EPA Substance Registry System: TERT-BUTYL N-(4-HYDROXYBUTYL)CARBAMATE(75178-87-9)

Safety Data

• WGK Germany: 3
• F: 10-21
• HazardClass: IRRITANT
• Hazardous Substances Data: 75178-87-9(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Liquid

Uses

Different sources of media describe the Uses of 75178-87-9 differently. You can refer to the following data:
1. Building block for spermidine analogues
2. 4-(tert-ButoxycarbonylaMino)-1-butanol can be used as an intermediate for the synthesis of polymers used for in vivo delivery polyconjugate systems.

InChI:InChI=1/C9H19NO3/c1-9(2,3)13-8(12)10-6-4-5-7-11/h11H,4-7H2,1-3H3,(H,10,12)

Upstream product

• 13325-10-5 4-Aminobutanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 57294-38-9 N-(tert-butoxycarbonyl)-4-aminobutanoic acid 
• 2508-29-4 5-hydroxypentylamine 
• 34619-03-9 tert-butyldicarbonate 
• 85909-08-6 tert-butyl 2-oxopyrrolidine-1-carboxylate 
• 67-63-0 isopropyl alcohol 
• 67-56-1 methanol 
• 104700-36-9 ethyl (2E)-4-[(tert-butoxycarbonyl)amino]but-2-enoate 

Downstream Products

• 84766-90-5 4-[N-(tert-butyloxycarbonyl)]amino-1-butanal 
• 164365-88-2 tert-butyl 4-bromobutylcarbamate 
• 436864-68-5 methyl 3-bromo-6-{4-[(tert-butoxycarbonyl)amino]butoxy}-2-hydroxybenzoate 
• 129392-85-4 N-t-butoxycarbonyl-4-azidobutylamine 
• 33545-98-1 N-(4-aminobutyl)carbaminsaeure-(tert-butyl)ester-hydrochlorid 
• 1046151-45-4 C₂₁H₂₈NO₄PS₂ 
• 1093206-52-0 tert-butyl 4-(2-cyano-3-nitrophenoxy)butylcarbamate 
• 180851-50-7 toluene-4-sulfonic acid 4-tert-butoxycarbonylaminobutyl ester 
• 1596369-26-4 tert-butyl (2-(2-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)ethoxy)ethyl)carbamate 
• 1596369-25-3 tert-butyl (5-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)pentyl)carbamate 
• 1596369-24-2 tert-butyl (4-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)butyl)carbamate 
• 1401564-76-8 tert-butyl (4-(benzyloxy)butyl)carbamate 
• 85909-04-2 4-tert-butoxycarbonylaminobutyric acid methyl ester 
• 1227780-28-0 2-(tert-butoxycarbonylamino)butyl methacrylate 

Relevant articles and documents

Biomimetic enterobactin analogue mediates iron-uptake and cargo transport intoE. coliandP. aeruginosa

The design, synthesis and biological evaluation of the artificial enterobactin analogueEntKLand several fluorophore-conjugates thereof are described.EntKLprovides an attachment point for cargos such as fluorophores or antimicrobial p

The synthesis of lysine α-ketoamide thrombin inhibitors via an epoxy amide ring opening

We describe a novel route for the preparation of substituted α-ketoamides of lysine. These compounds, due to the presence of an electrophilic carbonyl, display submicromolar activity toward the enzyme thrombin.

Novel Labelled Cannabinergic Ligands and Related Analogs

Novel cannabinoid ligands represented by the general formulas I, II, and III and methods for preparation and use within which one or more of a fluorescent ligand, nitroxide spin label, metal chelate, biotin moiety, or group with enhanced polarity may be incorporated. The compounds can bind to and modulate the cannabinoid CB1 and CB2 receptors and thereby considered specific ligands for these receptors. Some of the disclosed compounds that bind to cannabinoid CB1 and CB2 receptors can exhibit tight or irreversible binding characteristics for these receptors. Due to the presence of the imaging/diagnostic and/or therapeutic functional groups including fluorescent groups, nitroxide spin labels, metal chelates, biotin moieties, and groups with enhanced polarity, the disclosed compounds may be useful as imaging/diagnostic tools and/or therapeutic agents.

TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT

The present invention relates to a target protein degradation-inducing Degraducer, a preparation method thereof, and a pharmaceutical composition for preventing or treating diseases related to EED, EZH2, or PRC2 comprising same as an active ingredient. A novel compound represented by formula 1, according to the present invention is a Degraducer compound that induces degradation of a target protein, i.e., embryonic ectoderm development (EED) or polycomb repressive complex 2 (PRC2), utilizing cereblon E3 ubiquitin ligase, von Hippel-Lindau tumor suppressor (VHL) E3 ubiquitin ligase, mouse double minute 2 homolog (MDM2) E3 ubiquitin ligase, and cellular inhibitor of apoptosis protein 1 (cIAP) E3 ubiquitin ligase, wherein the compound has an aspect of remarkably achieving target protein degradation-inducing activity through a ubiquitin proteasome system (UPS), and therefore there is a useful effect in that it is possible to provide a pharmaceutical composition for preventing or treating diseases or conditions related to a target protein, and a functional health food composition for preventing or improving same, comprising said compound as an active ingredient.