C₄₁H₃₉Cl₃N₂O₈S

Base Information

• Chemical Name: C₄₁H₃₉Cl₃N₂O₈S
• CAS No.: 654644-04-9
• Molecular Formula: C₄₁H₃₉Cl₃N₂O₈S
• Molecular Weight: 826.194
• Mol file: 654644-04-9.mol

Synonyms:C₄₁H₃₉Cl₃N₂O₈S

Chemical Property of C₄₁H₃₉Cl₃N₂O₈S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₁H₃₉Cl₃N₂O₈S

There total 13 articles about C₄₁H₃₉Cl₃N₂O₈S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(R)-2-(2,2,2-Trichloro-ethoxycarbonylamino)-3-tritylsulfanyl-propionic acid (5R,7R,10R)-11-allyloxy-2,2,12-trimethyl-5,6,7,10-tetrahydro-4H-1,3,15,17-tetraoxa-6-aza-cyclopenta[a]phenanthren-7-ylmethyl ester (654644-03-8) → C22H25Cl3N2O8S + C41H39Cl3N2O8S (654644-04-9)

Guidance literature:

With trifluoroacetic acid; In toluene;

Reference yield:

Sesamol (533-31-3) → C41H39Cl3N2O8S (654644-04-9)

Guidance literature:

Multi-step reaction with 12 steps

1.1: 90 percent / NaH / diethyl ether; dimethylformamide / 0 °C

2.1: BuLi; TMEDA / hexane / 0 °C

2.2: 93 percent / hexane; diethyl ether / -78 - 20 °C

3.1: TMSCl; NaI / acetonitrile / -30 °C

3.2: 90 percent / KOH / acetonitrile

4.1: MeMgCl / tetrahydrofuran

4.2: 98 percent / CH₂Cl₂

5.1: Cs₂CO₃; NaI / dimethylformamide

6.1: p-TsOH / methanol / 0 °C

7.1: p-TsOH

8.1: TBDMSOTf; lutidine / -60 - 0 °C

8.2: 90 percent / KF / methanol / 20 °C

9.1: LiBr / toluene; 2,2,2-trifluoro-ethanol / 80 °C

10.1: 85 percent / LAH / tetrahydrofuran / -20 - 0 °C

11.1: 83 percent / EDCI; DMAP / CH₂Cl₂

12.1: TFA / toluene

With dmap; lithium aluminium tetrahydride; n-butyllithium; chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; lutidine; t-butyldimethylsiyl triflate; methylmagnesium chloride; sodium hydride; caesium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium iodide; lithium bromide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; 2,2,2-trifluoroethanol; N,N-dimethyl-formamide; toluene; acetonitrile; 9.1: Pictet-Spengler cyclization;

Reference yield:

3,4-(methylenedioxy)phenyl methoxymethyl ether (111726-43-3) → C41H39Cl3N2O8S (654644-04-9)

Guidance literature:

Multi-step reaction with 11 steps

1.1: BuLi; TMEDA / hexane / 0 °C

1.2: 93 percent / hexane; diethyl ether / -78 - 20 °C

2.1: TMSCl; NaI / acetonitrile / -30 °C

2.2: 90 percent / KOH / acetonitrile

3.1: MeMgCl / tetrahydrofuran

3.2: 98 percent / CH₂Cl₂

4.1: Cs₂CO₃; NaI / dimethylformamide

5.1: p-TsOH / methanol / 0 °C

6.1: p-TsOH

7.1: TBDMSOTf; lutidine / -60 - 0 °C

7.2: 90 percent / KF / methanol / 20 °C

8.1: LiBr / toluene; 2,2,2-trifluoro-ethanol / 80 °C

9.1: 85 percent / LAH / tetrahydrofuran / -20 - 0 °C

10.1: 83 percent / EDCI; DMAP / CH₂Cl₂

11.1: TFA / toluene

With dmap; lithium aluminium tetrahydride; n-butyllithium; chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; lutidine; t-butyldimethylsiyl triflate; methylmagnesium chloride; caesium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium iodide; lithium bromide; In tetrahydrofuran; methanol; hexane; dichloromethane; 2,2,2-trifluoroethanol; N,N-dimethyl-formamide; toluene; acetonitrile; 8.1: Pictet-Spengler cyclization;

upstream raw materials:

(R)-2-(2,2,2-Trichloro-ethoxycarbonylamino)-3-tritylsulfanyl-propionic acid (5R,7R,10R)-11-allyloxy-2,2,12-trimethyl-5,6,7,10-tetrahydro-4H-1,3,15,17-tetraoxa-6-aza-cyclopenta[a]phenanthren-7-ylmethyl ester

Sesamol

3,4-(methylenedioxy)phenyl methoxymethyl ether

(R)-N-2,2,2-trichloroethoxycarbonyl-(S-trityl)cysteine