1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-(2,4-dimethoxybenzyl)-N-methylmethanamine

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Chemical Name:1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-(2,4-dimethoxybenzyl)-N-methylmethanamine
CAS No.:1055306-79-0
Molecular Formula:C₂₆H₂₅ClFN₃O₄S
Molecular Weight:530.02
Hs Code.:

Synonyms:1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-(2,4-dimethoxybenzyl)-N-methylmethanamine

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Chemical Property of 1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-(2,4-dimethoxybenzyl)-N-methylmethanamine

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Technology Process of 1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-(2,4-dimethoxybenzyl)-N-methylmethanamine

There total 6 articles about 1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-(2,4-dimethoxybenzyl)-N-methylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1055306-74-5
1-[5-(2-chloropyridin-3-yl)-4-fluoro-1H-pyrrol-3-yl]-N-(2,4-dimethoxybenzyl)-N-methylmethanamine

: 98-09-9
benzenesulfonyl chloride

: 1055306-79-0
1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-(2,4-dimethoxybenzyl)-N-methylmethanamine

Guidance literature:: 1-[5-(2-chloropyridin-3-yl)-4-fluoro-1H-pyrrol-3-yl]-N-(2,4-dimethoxybenzyl)-N-methylmethanamine; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

benzenesulfonyl chloride; With 15-crown-5; In tetrahydrofuran; at 0 ℃; for 0.5h;

Reference yield:

: 1055306-63-2
tert-butyl (4RS)-4-(bromomethyl)-3,3-difluoro-2-oxopyrrolidine-1-carboxylate

: 1055306-79-0
1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-(2,4-dimethoxybenzyl)-N-methylmethanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1.25 h / 0 - 20 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.75 h / -78 °C

2.2: 3 h / -78 °C

3.1: hydrogenchloride; water; acetic acid / 1 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 16 h / 0 - 60 °C

4.2: 0.5 h / 0 °C

5.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

5.2: 0.5 h / 0 °C

With hydrogenchloride; n-butyllithium; water; sodium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropylamine; In tetrahydrofuran; hexane;

Reference yield:

: 1055306-62-1
tert-butyl [bromo(difluoro)acetyl]prop-2-en-1-ylcarbamate

: 1055306-79-0
1-[5-(2-chloropyridin-3-yl)-4-fluoro-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-(2,4-dimethoxybenzyl)-N-methylmethanamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: [2,2]bipyridinyl; copper(ll) bromide / 1,2-dichloro-ethane / 24 h / 80 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1.25 h / 0 - 20 °C

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.75 h / -78 °C

3.2: 3 h / -78 °C

4.1: hydrogenchloride; water; acetic acid / 1 h / 20 °C

5.1: sodium hydride / tetrahydrofuran / 16 h / 0 - 60 °C

5.2: 0.5 h / 0 °C

6.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

6.2: 0.5 h / 0 °C

With hydrogenchloride; [2,2]bipyridinyl; n-butyllithium; water; sodium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropylamine; copper(ll) bromide; In tetrahydrofuran; hexane; 1,2-dichloro-ethane;