Tetrahydrofuran-2-carboxamide

Base Information

• Chemical Name: Tetrahydrofuran-2-carboxamide
• CAS No.: 91470-28-9
• Molecular Formula: C5H9 N O2
• Molecular Weight: 115.132
• Hs Code.: 2932190090
• European Community (EC) Number: 855-165-9
• DSSTox Substance ID: DTXSID90393498
• Nikkaji Number: J2.000.451G
• Mol file: 91470-28-9.mol

Synonyms:Tetrahydrofuran-2-carboxamide;91470-28-9;Oxolane-2-carboxamide;2-Furancarboxamide, tetrahydro-;MFCD03929553;SCHEMBL745665;DTXSID90393498;GXHAENUAJYZNOA-UHFFFAOYSA-N;AKOS008937796;CS-11262;SY012530;CS-0149957;FT-0724385;EN300-79202;A860365;Z33545380

Chemical Property of Tetrahydrofuran-2-carboxamide

Chemical Property:

• PSA: 52.32000
• LogP: 0.35100
• Storage Temp.: 2-8°C
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 115.063328530
• Heavy Atom Count: 8
• Complexity: 103

Purity/Quality:

99% ^*data from raw suppliers

Tetrahydrofuran-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(OC1)C(=O)N

Technology Process of Tetrahydrofuran-2-carboxamide

There total 8 articles about Tetrahydrofuran-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

tetrahydro-2-furancarboxylic acid (16874-33-2) + chloroformic acid ethyl ester (541-41-3) → tetrahydrofuran-2-carboxamide (91470-28-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; ethyl acetate;

Reference yield:

→ tetrahydro-2-furancarboxylic acid (16874-33-2) + tetrahydrofuran-2-carboxamide (91470-28-9)

Guidance literature:

With ammonium hydroxide; nickel cyanide; at 135 ℃; under 51485.6 Torr;

Reference yield:

tetrahydro-2-furancarboxylic acid (16874-33-2) → tetrahydrofuran-2-carboxamide (91470-28-9)

Guidance literature:

With ammonia; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.03.038

upstream raw materials:

furan-2-carboxylic acid amide

ethyl tetrahydrofurancarboxylate

tetrahydro-2-furancarboxylic acid

chloroformic acid ethyl ester

Downstream raw materials:

tetrahydro-2-furancarboximidamide hydrochloride

tetrahydrofuran-2-carboximidamide

2-tetrahydrofuran-2-carbonitrile

penta-2,4-dienenitrile