benzyl (5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate

Base Information

Chemical Name:benzyl (5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate
CAS No.:1228935-32-7
Molecular Formula:C₂₅H₂₀N₄O₃
Molecular Weight:424.459
Hs Code.:

Synonyms:benzyl (5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate

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Chemical Property of benzyl (5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate

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Technology Process of benzyl (5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate

There total 1 articles about benzyl (5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 137731-25-0
1-phenyl-4H-<1,2,4>-triazolo<4,3-a><1,5>benzodiazepin-5(6H)-one

: 5437-45-6
Benzyl bromoacetate

: 1228935-32-7
benzyl (5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate

Guidance literature:: 1-phenyl-4H-<1,2,4>-triazolo<4,3-a><1,5>benzodiazepin-5(6H)-one; With potassium hexamethylsilazane; In N,N-dimethyl-formamide; toluene; at -20 ℃;

Benzyl bromoacetate; In N,N-dimethyl-formamide; toluene; at -20 - 20 ℃; for 15h;

Reference yield: 67.0%

: 1228935-32-7
benzyl (5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate

: C₁₄H₁₇BrN₂O₂

: tert-butyl-[3-({6-[2-(benzyloxy)-2-oxoethyl]-5-oxo-1-phenyl-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-4-yl}methyl)-1H-indazol-1-yl]acetate

Guidance literature:: benzyl (5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

C₁₄H₁₇BrN₂O₂; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

Reference yield:

: 1228935-32-7
benzyl (5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate

: 1228935-36-1
{4-[(1-{2-[methyl(propyl)amino]-2-oxoethyl}-1H-indazol-3-yl)methyl]-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl}acetic acid.

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

1.2: 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 15 h / 20 °C

3.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / ethyl acetate; N,N-dimethyl-formamide / 72 h / 40 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 3087.28 Torr / Parr shaker; Inert atmosphere

With hydrogen; sodium hydride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;