2-[3-({6-[2-(2-isopropylpiperidin-1-yl)-2-oxoethyl]-5-oxo-1-phenyl-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-4-yl}methyl)-1H-indazol-1-yl]-N-methyl-N-propylacetamide

Base Information

Chemical Name:2-[3-({6-[2-(2-isopropylpiperidin-1-yl)-2-oxoethyl]-5-oxo-1-phenyl-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-4-yl}methyl)-1H-indazol-1-yl]-N-methyl-N-propylacetamide
CAS No.:1228934-68-6
Molecular Formula:C₄₀H₄₆N₈O₃
Molecular Weight:686.857
Hs Code.:

2-[3-({6-[2-(2-isopropylpiperidin-1-yl)-2-oxoethyl]-5-oxo-1-phenyl-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-4-yl}methyl)-1H-indazol-1-yl]-N-methyl-N-propylacetamide

Synonyms:2-[3-({6-[2-(2-isopropylpiperidin-1-yl)-2-oxoethyl]-5-oxo-1-phenyl-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-4-yl}methyl)-1H-indazol-1-yl]-N-methyl-N-propylacetamide

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Chemical Property of 2-[3-({6-[2-(2-isopropylpiperidin-1-yl)-2-oxoethyl]-5-oxo-1-phenyl-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-4-yl}methyl)-1H-indazol-1-yl]-N-methyl-N-propylacetamide

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Technology Process of 2-[3-({6-[2-(2-isopropylpiperidin-1-yl)-2-oxoethyl]-5-oxo-1-phenyl-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-4-yl}methyl)-1H-indazol-1-yl]-N-methyl-N-propylacetamide

There total 5 articles about 2-[3-({6-[2-(2-isopropylpiperidin-1-yl)-2-oxoethyl]-5-oxo-1-phenyl-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-4-yl}methyl)-1H-indazol-1-yl]-N-methyl-N-propylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1228935-36-1
{4-[(1-{2-[methyl(propyl)amino]-2-oxoethyl}-1H-indazol-3-yl)methyl]-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl}acetic acid.

: 116836-22-7
2-(sec-butyl)piperidine

: 1228934-68-6
2-[3-({6-[2-(2-isopropylpiperidin-1-yl)-2-oxoethyl]-5-oxo-1-phenyl-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-4-yl}methyl)-1H-indazol-1-yl]-N-methyl-N-propylacetamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; at 50 ℃;

Reference yield:

: 1228935-34-9
[3-({6-[2-(benzyloxy)-2-oxoethyl]-5-oxo-1-phenyl-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-4-yl}methyl)-1H-indazol-1-yl]acetic acid

: 1228934-68-6
2-[3-({6-[2-(2-isopropylpiperidin-1-yl)-2-oxoethyl]-5-oxo-1-phenyl-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-4-yl}methyl)-1H-indazol-1-yl]-N-methyl-N-propylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / ethyl acetate; N,N-dimethyl-formamide / 72 h / 40 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 3087.28 Torr / Parr shaker; Inert atmosphere

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 50 °C

With hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: tert-butyl-[3-({6-[2-(benzyloxy)-2-oxoethyl]-5-oxo-1-phenyl-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-4-yl}methyl)-1H-indazol-1-yl]acetate

: 1228934-68-6
2-[3-({6-[2-(2-isopropylpiperidin-1-yl)-2-oxoethyl]-5-oxo-1-phenyl-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-4-yl}methyl)-1H-indazol-1-yl]-N-methyl-N-propylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 15 h / 20 °C

2: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / ethyl acetate; N,N-dimethyl-formamide / 72 h / 40 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 3087.28 Torr / Parr shaker; Inert atmosphere

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 50 °C

With hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;