4-ethoxycarbonylmethyl-2-imino-3-phenacyl-2,3-dihydrothiazole

Base Information

• Chemical Name: 4-ethoxycarbonylmethyl-2-imino-3-phenacyl-2,3-dihydrothiazole
• CAS No.: 121953-08-0
• Molecular Formula: C₁₅H₁₆N₂O₃S
• Molecular Weight: 304.37
• Mol file: 121953-08-0.mol

Synonyms:4-ethoxycarbonylmethyl-2-imino-3-phenacyl-2,3-dihydrothiazole

Chemical Property of 4-ethoxycarbonylmethyl-2-imino-3-phenacyl-2,3-dihydrothiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ethoxycarbonylmethyl-2-imino-3-phenacyl-2,3-dihydrothiazole

There total 4 articles about 4-ethoxycarbonylmethyl-2-imino-3-phenacyl-2,3-dihydrothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

Bromhydrate d'(imino-2 phenacyl-3 thiazolinyl-4)acetate d'ethyle → 4-ethoxycarbonylmethyl-2-imino-3-phenacyl-2,3-dihydrothiazole (121953-08-0)

Guidance literature:

With sodium hydrogencarbonate; In chloroform; at 20 ℃; for 0.333333h;

Reference yield:

ethyl 2-amino-1,3-thiazol-4-acetate (53266-94-7) + α-bromoacetophenone (70-11-1) → 4-ethoxycarbonylmethyl-2-imino-3-phenacyl-2,3-dihydrothiazole (121953-08-0)

Guidance literature:

In acetone; for 24h; Ambient temperature;

Reference yield:

ethyl 2-amino-1,3-thiazol-4-acetate (53266-94-7) → 4-ethoxycarbonylmethyl-2-imino-3-phenacyl-2,3-dihydrothiazole (121953-08-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / acetone / 24 h / 20 °C

2: 59 percent / 1M aq. NaHCO₃ / CHCl₃ / 0.33 h / 20 °C

With sodium hydrogencarbonate; In chloroform; acetone;

upstream raw materials:

ethyl 2-amino-1,3-thiazol-4-acetate

α-bromoacetophenone

Downstream raw materials:

3-ethoxycarbonylmethyl-6-phenylimidazo<2,1-b>thiazole

4-ethoxycarbomylmethyl-3-phenacyl-2-(2-thenoylimino)-2,3-dihydrothiazole

4-ethoxycarbonylmethyl-3-phenacyl-2-trifluoroacetylimino-2,3-dihydrothiazole

6-phenylimidazo<2,1-b>thiazole-3-acetic acid