6β-((R)-2-benzylideneamino-2-phenyl-acetylamino)-penicillanic acid; triethylamine salt

Base Information

• Chemical Name: 6β-((R)-2-benzylideneamino-2-phenyl-acetylamino)-penicillanic acid; triethylamine salt
• CAS No.: 59331-13-4
• Molecular Formula: C₆H₁₅N*C₂₃H₂₃N₃O₄S
• Molecular Weight: 538.711
• Mol file: 59331-13-4.mol

Synonyms:6β-((R)-2-benzylideneamino-2-phenyl-acetylamino)-penicillanic acid; triethylamine salt

Chemical Property of 6β-((R)-2-benzylideneamino-2-phenyl-acetylamino)-penicillanic acid; triethylamine salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6β-((R)-2-benzylideneamino-2-phenyl-acetylamino)-penicillanic acid; triethylamine salt

There total 1 articles about 6β-((R)-2-benzylideneamino-2-phenyl-acetylamino)-penicillanic acid; triethylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ampicillin (69-53-4) + benzaldehyde (100-52-7) + triethylamine (121-44-8) → 6β-((R)-2-benzylideneamino-2-phenyl-acetylamino)-penicillanic acid; triethylamine salt (59331-13-4)

Guidance literature:

In dichloromethane; for 0.5h;

DOI:10.1248/cpb.24.102

Reference yield:

6β-((R)-2-benzylideneamino-2-phenyl-acetylamino)-penicillanic acid; triethylamine salt (59331-13-4) → talampicillin (47747-56-8)

Guidance literature:

Multi-step reaction with 2 steps

1: KHCO₃ / dimethylformamide / 2 h / 0 - 5 °C

2: aq. HCl / acetonitrile / Ambient temperature

With hydrogenchloride; potassium hydrogencarbonate; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1248/cpb.24.102

Reference yield:

3-Bromophthalide (6940-49-4) + 6β-((R)-2-benzylideneamino-2-phenyl-acetylamino)-penicillanic acid; triethylamine salt (59331-13-4) → 6β-((R)-2-benzylideneamino-2-phenyl-acetylamino)-penicillanic acid (Ξ)-3-oxo-1,3-dihydro-isobenzofuran-1-yl ester (59225-72-8)

Guidance literature:

With potassium hydrogencarbonate; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 2h;

DOI:10.1248/cpb.24.102

upstream raw materials:

ampicillin

benzaldehyde

triethylamine

Downstream raw materials:

6β-((R)-2-benzylideneamino-2-phenyl-acetylamino)-penicillanic acid (Ξ)-3-oxo-1,3-dihydro-isobenzofuran-1-yl ester

talampicillin