Boronic acid, [4-methoxy-3-(phenylmethyl)phenyl]-

Base Information

Chemical Name:Boronic acid, [4-methoxy-3-(phenylmethyl)phenyl]-
CAS No.:475272-16-3
Molecular Formula:C₁₄H₁₅BO₃
Molecular Weight:242.082
Hs Code.:
DSSTox Substance ID:DTXSID901233978

Synonyms:475272-16-3;Boronic acid, [4-methoxy-3-(phenylmethyl)phenyl]-;(3-benzyl-4-methoxyphenyl)boronic acid;SCHEMBL4652546;UAVVPTNWMCWFRE-UHFFFAOYSA-N;DTXSID901233978;3-benzyl-4-methoxy-benzene-1-boronic acid;E93416

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Boronic acid, [4-methoxy-3-(phenylmethyl)phenyl]-

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:242.1114245
Heavy Atom Count:18
Complexity:241

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:B(C1=CC(=C(C=C1)OC)CC2=CC=CC=C2)(O)O

Technology Process of Boronic acid, [4-methoxy-3-(phenylmethyl)phenyl]-

There total 1 articles about Boronic acid, [4-methoxy-3-(phenylmethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: B(OMe)3

: 41876-52-2
2-benzyl-4-bromoanisole

: 475272-16-3
3-benzyl-4-methoxy-benzene-1-boronic acid

Guidance literature:: With n-butyllithium; In tetrahydrofuran; water;

Reference yield: 52.0%

: 475272-16-3
3-benzyl-4-methoxy-benzene-1-boronic acid

: 434300-54-6
4-(2-cyanoethyl)-2-isobutylphenyl trifluoromethanesulfonate

: 475272-18-5
3-(3'-benzyl-2-isobutyl-4'-methoxy-1,1'-biphenyl-4-yl)propanenitrile

Guidance literature:: With sodium carbonate; In 1,2-dimethoxyethane; ethanol; at 80 ℃; for 17h;
DOI:10.1021/ja026861k

Reference yield:

: 475272-16-3
3-benzyl-4-methoxy-benzene-1-boronic acid

: 475272-35-6
3-(3'-benzyl-4''-(cyanomethoxy)-2,3''-diisobutyl-1,1':4',1''-terphenyl-4-yl)propanenitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 52 percent / aq. Na₂CO₃ / 1,2-dimethoxy-ethane; ethanol / 17 h / 80 °C

2: 96 percent / BBr₃ / CH₂Cl₂ / 9 h / 0 - 20 °C

3: 85 percent / pyridine / 18 h / 0 - 20 °C

4: 88.26 percent / Pd(Ph₃P)4; aq. Na₂CO₃ / 1,2-dimethoxy-ethane; ethanol / 19 h / 80 °C

5: 99.91 percent / BBr₃ / CH₂Cl₂ / 6.5 h / 0 - 20 °C

6: 91.43 percent / K₂CO₃ / acetone / 40 h / 55 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; sodium carbonate; potassium carbonate; In 1,2-dimethoxyethane; ethanol; dichloromethane; acetone;
DOI:10.1021/ja026861k