Technology Process of (2R,3Z,6E)-1-(tert-butyldiphenylsiloxy)-10-(methoxymethyloxy)-2,4-dimethyl-3,6-decadiene
There total 6 articles about (2R,3Z,6E)-1-(tert-butyldiphenylsiloxy)-10-(methoxymethyloxy)-2,4-dimethyl-3,6-decadiene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(1E)-5-(methoxymethyloxy)-1-pentenyl iodide;
With
tert.-butyl lithium;
In
tetrahydrofuran; pentane;
at -78 ℃;
for 0.0833333h;
(2Z,4R)-5-(tert-butyldiphenylsiloxy)-2,4-dimethyl-2-pentenyl bromide;
With
N,N,N,N,N,N-hexamethylphosphoric triamide;
In
tetrahydrofuran; pentane;
at -78 ℃;
for 0.5h;
DOI:10.1016/S0040-4020(01)00593-2
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 18-crown-6; KHMDS / tetrahydrofuran; toluene / 0.25 h / -78 °C
1.2: 1.13 g / tetrahydrofuran; toluene / 3 h / -78 - -10 °C
2.1: 94 percent / DIBAL / diethyl ether; hexane / 0.5 h / -78 °C
3.1: 99 percent / CBr4; PPh3 / acetonitrile / 0.33 h / 0 - 20 °C
4.1: t-BuLi / tetrahydrofuran; pentane / 0.08 h / -78 °C
4.2: 53 percent / HMPA / tetrahydrofuran; pentane / 0.5 h / -78 °C
With
18-crown-6 ether; carbon tetrabromide; tert.-butyl lithium; potassium hexamethylsilazane; diisobutylaluminium hydride; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; hexane; toluene; acetonitrile; pentane;
1.2: Still-Horner olefination;
DOI:10.1016/S0040-4020(01)00593-2
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: DIBAL / diethyl ether; hexane / 0.33 h / -78 °C
2.1: 18-crown-6; KHMDS / tetrahydrofuran; toluene / 0.25 h / -78 °C
2.2: 1.13 g / tetrahydrofuran; toluene / 3 h / -78 - -10 °C
3.1: 94 percent / DIBAL / diethyl ether; hexane / 0.5 h / -78 °C
4.1: 99 percent / CBr4; PPh3 / acetonitrile / 0.33 h / 0 - 20 °C
5.1: t-BuLi / tetrahydrofuran; pentane / 0.08 h / -78 °C
5.2: 53 percent / HMPA / tetrahydrofuran; pentane / 0.5 h / -78 °C
With
18-crown-6 ether; carbon tetrabromide; tert.-butyl lithium; potassium hexamethylsilazane; diisobutylaluminium hydride; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; hexane; toluene; acetonitrile; pentane;
2.2: Still-Horner olefination;
DOI:10.1016/S0040-4020(01)00593-2
