2-(2-(4-N-(3,5-di-tert-butyl-4-hydroxyphenylcarboxy)aminophenyl))ethylamino-N⁽⁶⁾-(2,2-diphenylethyl)-2',3'-isopropylideneadenosine-5'-N-ethylcarboxamide

Base Information

• Chemical Name: 2-(2-(4-N-(3,5-di-tert-butyl-4-hydroxyphenylcarboxy)aminophenyl))ethylamino-N⁽⁶⁾-(2,2-diphenylethyl)-2',3'-isopropylideneadenosine-5'-N-ethylcarboxamide
• CAS No.: 1365619-30-2
• Molecular Formula: C₅₂H₆₂N₈O₆
• Molecular Weight: 895.114

Synonyms:2-(2-(4-N-(3,5-di-tert-butyl-4-hydroxyphenylcarboxy)aminophenyl))ethylamino-N⁽⁶⁾-(2,2-diphenylethyl)-2',3'-isopropylideneadenosine-5'-N-ethylcarboxamide

Chemical Property of 2-(2-(4-N-(3,5-di-tert-butyl-4-hydroxyphenylcarboxy)aminophenyl))ethylamino-N⁽⁶⁾-(2,2-diphenylethyl)-2',3'-isopropylideneadenosine-5'-N-ethylcarboxamide

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Technology Process of 2-(2-(4-N-(3,5-di-tert-butyl-4-hydroxyphenylcarboxy)aminophenyl))ethylamino-N⁽⁶⁾-(2,2-diphenylethyl)-2',3'-isopropylideneadenosine-5'-N-ethylcarboxamide

There total 6 articles about 2-(2-(4-N-(3,5-di-tert-butyl-4-hydroxyphenylcarboxy)aminophenyl))ethylamino-N⁽⁶⁾-(2,2-diphenylethyl)-2',3'-isopropylideneadenosine-5'-N-ethylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

2-(4-N-(3,5-di-tert-butyl-4-hydroxyphenylcarboxy)aminophenyl)ethylamine (1365619-25-5) + 2-fluoro-N(6)-(2,2-diphenylethyl)-2',3'-O-isopropylideneadenosine-5'-N-ethylcarboxamide (1365619-11-9) → 2-(2-(4-N-(3,5-di-tert-butyl-4-hydroxyphenylcarboxy)aminophenyl))ethylamino-N(6)-(2,2-diphenylethyl)-2',3'-isopropylideneadenosine-5'-N-ethylcarboxamide (1365619-30-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; at 70 ℃; for 168h;

DOI:10.1021/jm300206u

Reference yield:

p-Aminophenethylamine (13472-00-9) → 2-(2-(4-N-(3,5-di-tert-butyl-4-hydroxyphenylcarboxy)aminophenyl))ethylamino-N(6)-(2,2-diphenylethyl)-2',3'-isopropylideneadenosine-5'-N-ethylcarboxamide (1365619-30-2)

Guidance literature:

Multi-step reaction with 4 steps

1: dichloromethane / 0.75 h / -5 - 0 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 25 °C

3: trifluoroacetic acid / dichloromethane / 3 h / 25 °C

4: N-ethyl-N,N-diisopropylamine / ethanol / 168 h / 70 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm300206u

Reference yield:

2,2-Diphenylethylamine (3963-62-0) → 2-(2-(4-N-(3,5-di-tert-butyl-4-hydroxyphenylcarboxy)aminophenyl))ethylamino-N(6)-(2,2-diphenylethyl)-2',3'-isopropylideneadenosine-5'-N-ethylcarboxamide (1365619-30-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 0 - 25 °C

2: N-ethyl-N,N-diisopropylamine / ethanol / 168 h / 70 °C

With N-ethyl-N,N-diisopropylamine; In ethanol; acetonitrile;

DOI:10.1021/jm300206u

upstream raw materials:

p-Aminophenethylamine

2-fluoro-O⁽⁶⁾-(benzotriazol-1-yl)-2',3'-O-isopropylideneinosine-5'-N-ethylcarboxamide

N-(tert-butoxycarbonyl)-2-(4-N-(3,5-di-tert-butyl-4-hydroxyphenylcarboxy)aminophenyl)ethylamine

2-(4-N-(3,5-di-tert-butyl-4-hydroxyphenylcarboxy)aminophenyl)ethylamine

Downstream raw materials:

2-(2-(4-N-(3,5-di-tert-butyl-4-hydroxyphenylcarboxy)aminophenyl))ethylamino-N⁽⁶⁾-(2,2-diphenylethyl)adenosine-5'-N-ethylcarboxamide

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