3-chloro-4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide

Base Information

Chemical Name:3-chloro-4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide
CAS No.:1552280-90-6
Molecular Formula:C₂₄H₁₉ClFN₅O₄
Molecular Weight:495.897
Hs Code.:

Synonyms:3-chloro-4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide

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Chemical Property of 3-chloro-4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide

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Technology Process of 3-chloro-4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide

There total 4 articles about 3-chloro-4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.2%

: 1025721-01-0
4-(4-amino-2-fluorophenoxy)-3-chloropyridine-2-carboxamide

: 83-10-3
antipyric acid

: 1552280-90-6
3-chloro-4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 45 ℃; for 14.5h;

Reference yield:

: 403-19-0
2-fluoro-4-nitrophenol

: 1552280-90-6
3-chloro-4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 2 h / 120 °C / Microwave irradiation

3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14.5 h / 45 °C

With 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 55934-00-4
3,4-dichloropyridine

: 1552280-90-6
3-chloro-4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; 2,2,6,6-tetramethyl-piperidine / diethyl ether; hexane / 2.25 h / -78 °C

1.2: 2 h / -78 - 20 °C

1.3: 20 °C

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 2 h / 120 °C / Microwave irradiation

3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14.5 h / 45 °C

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; 1-hydroxy-7-aza-benzotriazole; potassium tert-butylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;