methyl 2,2-dimethyl-3-(4-{5-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-2-yl}phenoxy)-propanoate

Base Information

Chemical Name:methyl 2,2-dimethyl-3-(4-{5-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-2-yl}phenoxy)-propanoate
CAS No.:1382998-75-5
Molecular Formula:C₂₁H₂₀F₃N₃O₃
Molecular Weight:419.403
Hs Code.:

Synonyms:methyl 2,2-dimethyl-3-(4-{5-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-2-yl}phenoxy)-propanoate

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Chemical Property of methyl 2,2-dimethyl-3-(4-{5-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-2-yl}phenoxy)-propanoate

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Technology Process of methyl 2,2-dimethyl-3-(4-{5-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-2-yl}phenoxy)-propanoate

There total 5 articles about methyl 2,2-dimethyl-3-(4-{5-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-2-yl}phenoxy)-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1382998-74-4
methyl 2,2-dimethyl-3-(4-{5-[4-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyridin-2-yl}phenoxy)propanoate

: 1382998-75-5
methyl 2,2-dimethyl-3-(4-{5-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-2-yl}phenoxy)-propanoate

Guidance literature:: methyl 2,2-dimethyl-3-(4-{5-[4-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyridin-2-yl}phenoxy)propanoate; With water; trifluoroacetic acid; at 20 ℃; Cooling with ice;

With sodium hydrogencarbonate; In chloroform; water;

Reference yield:

: 149806-06-4
6-bromonicotinaldehyde

: 1382998-75-5
methyl 2,2-dimethyl-3-(4-{5-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-2-yl}phenoxy)-propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium acetate / water / 0.5 h / 95 °C

1.2: 20 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Cooling with ice

2.2: 20 °C / Cooling with ice

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 65 °C / Inert atmosphere

4.1: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 5 h / 20 °C / Inert atmosphere

5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 70 °C / Cooling with ice

6.1: water; trifluoroacetic acid / 20 °C / Cooling with ice

With water; hydrogen; sodium acetate; sodium hydride; sodium carbonate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1382998-88-0
2-bromo-5-[4-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole-2-yl]pyridine

: 1382998-75-5
methyl 2,2-dimethyl-3-(4-{5-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-2-yl}phenoxy)-propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 65 °C / Inert atmosphere

2: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 5 h / 20 °C / Inert atmosphere

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 70 °C / Cooling with ice

4: water; trifluoroacetic acid / 20 °C / Cooling with ice

With water; hydrogen; sodium carbonate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;