(2S)-4-methyl-2-<<(2S)-2-(5-oxo-5,7-dihydropyrrolo<3,4-b>pyridin-6-yl)-3-phenylpropionyl>amino>pentanoic acid

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Chemical Name:(2S)-4-methyl-2-<<(2S)-2-(5-oxo-5,7-dihydropyrrolo<3,4-b>pyridin-6-yl)-3-phenylpropionyl>amino>pentanoic acid
CAS No.:137282-15-6
Molecular Formula:C₂₂H₂₅N₃O₄
Molecular Weight:395.458
Hs Code.:

Synonyms:(2S)-4-methyl-2-<<(2S)-2-(5-oxo-5,7-dihydropyrrolo<3,4-b>pyridin-6-yl)-3-phenylpropionyl>amino>pentanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-4-methyl-2-<<(2S)-2-(5-oxo-5,7-dihydropyrrolo<3,4-b>pyridin-6-yl)-3-phenylpropionyl>amino>pentanoic acid

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Technology Process of (2S)-4-methyl-2-<<(2S)-2-(5-oxo-5,7-dihydropyrrolo<3,4-b>pyridin-6-yl)-3-phenylpropionyl>amino>pentanoic acid

There total 2 articles about (2S)-4-methyl-2-<<(2S)-2-(5-oxo-5,7-dihydropyrrolo<3,4-b>pyridin-6-yl)-3-phenylpropionyl>amino>pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 137282-14-5
(2S)-4-methyl-2-<<(2S)-2-(5-oxo-5,7-dihydropyrrolo<3,4-b>pyridin-6-yl)-3-phenylpropionyl>amino>pentanoic acid methyl ester

: 137282-15-6
(2S)-4-methyl-2-<<(2S)-2-(5-oxo-5,7-dihydropyrrolo<3,4-b>pyridin-6-yl)-3-phenylpropionyl>amino>pentanoic acid

Guidance literature:: With sodium hydroxide; In methanol;
DOI:10.1021/jm00083a005

Reference yield:

: 21908-07-6
2-formyl-3-pyridinecarboxylic acid ethyl ester

: 137282-15-6
(2S)-4-methyl-2-<<(2S)-2-(5-oxo-5,7-dihydropyrrolo<3,4-b>pyridin-6-yl)-3-phenylpropionyl>amino>pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) NaCNBH₃ / 1.) MeOH, 5 min, 2.) MeOH, reflux, overnight

2: 91 percent / 1 N aq. NaOH / methanol

With sodium hydroxide; sodium cyanoborohydride; In methanol;
DOI:10.1021/jm00083a005

Reference yield:

: 137282-15-6
(2S)-4-methyl-2-<<(2S)-2-(5-oxo-5,7-dihydropyrrolo<3,4-b>pyridin-6-yl)-3-phenylpropionyl>amino>pentanoic acid

: 137282-07-6,139101-45-4,139130-52-2
(S)-3-Amino-4-cyclohexyl-2-hydroxy-butyric acid methyl ester; compound with trifluoro-acetic acid

: 137281-93-7
(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-4-methyl-2-<<(2S)-2-(5-oxo-5,7-dihydropyrrolo<3,4-b>pyridin-6-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid methyl ester

Guidance literature:: With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; benzotriazol-1-ol; Yield given. Multistep reaction; 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₂Cl₂, RT, overnight;
DOI:10.1021/jm00083a005