21908-07-6Relevant articles and documents
Heterocyclic compounds as ligands of the GABAA receptor
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, (2008/06/13)
Disclosed are heterocyclic compounds of the formula and the pharmaceutically acceptable salts thereof wherein the variables A, V, Y, J, E, X, T, G, Q, W, Z, b, n and m are defined herein. These compounds are highly selective agonists, antagonists or inverse agonists for GABAA brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAA brain receptor.
CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS
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, (2008/06/13)
Tertiary amines containing a multiplicity of heteroaromatic substituents are useful as chemokine receptor modulators.
Synthesis of 6-Phenyl Substituted 2-Formylnicotinates
Graef, Edgar,Troschuetz, Reinhard
, p. 1216 - 1222 (2007/10/03)
A verastile synthesis of 2-formylnicotinates 6 (R' = Me) and 7 (R' = Et) is described. 6-Phenyl substituted 2-diethoxymethylnicotinates 14/15 are prepared first starting by cyclocondensation of 3-amino-4,4-diethoxybut-2-enoates 12/13 with Mannich base hydrochlorides 1 or β-aminovinyl ketones 16. Subsequent hydrolysis of the acetal function in 14/15 gives rise to the title compounds.
Heterocyclic hydrazines and hydrazones
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, (2008/06/13)
N-carbamoyl-2-carboxyaryl-heterocyclic and hydrazinecarboximidamide-hydrazone derivatives, intermediates and processes for their preparation, agricultural compositions containing them and their use as agricultural chemicals, in particular herbicides.
Synthesis of 2-Aryl-2,3-dihydro-oxazolopyrrolopyridin-5-one and 2-Aryl-2,3-dihydro-oxazolopyrrolopyridin-5-one
Makki, Mohamad S. I.,Samarkandy, Abdul-Rahim A.,Kabuli, Rida A.,Hewlins, M. J. E.
, p. 75 - 80 (2007/10/02)
A variety of 2-aryl-2,3-dihydro-oxazolopyrrolopyridin-5-one and 2-aryl-2,3-dihydro-oxazolopyrrolopyridin-5-one were prepared. The absolute configuration of the chiral centers were studied thoroughly from which the structural and stereoformulea of these compounds were deduced by using nmr and microanalysis technique.
Substituted semi-carbazones and related compounds
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, (2008/06/13)
Substituted semicarbazones, thiosemicarbazones and isothiosemicarbazones and salts thereof, intermediates therefor, synthesis thereof, and the use of said compounds for the control of weeds.
Antihypertensive benzopyran derivatives
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, (2008/06/13)
Disclosed herein are novel benzopyrans having pharmacological activity, to a process for preparing them, to pharmaceutical compositions containing them, and to their use in the treatment of hypertension.