7-tert-butyl-3-[3-chloro-2-(hydroxymethyl)phenyl]-4-oxo-3,4-dihydrophthalazine-5-carbonitrile

Base Information

Chemical Name:7-tert-butyl-3-[3-chloro-2-(hydroxymethyl)phenyl]-4-oxo-3,4-dihydrophthalazine-5-carbonitrile
CAS No.:1413063-83-8
Molecular Formula:C₂₀H₁₈ClN₃O₂
Molecular Weight:367.835
Hs Code.:

Synonyms:7-tert-butyl-3-[3-chloro-2-(hydroxymethyl)phenyl]-4-oxo-3,4-dihydrophthalazine-5-carbonitrile

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Chemical Property of 7-tert-butyl-3-[3-chloro-2-(hydroxymethyl)phenyl]-4-oxo-3,4-dihydrophthalazine-5-carbonitrile

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Technology Process of 7-tert-butyl-3-[3-chloro-2-(hydroxymethyl)phenyl]-4-oxo-3,4-dihydrophthalazine-5-carbonitrile

There total 1 articles about 7-tert-butyl-3-[3-chloro-2-(hydroxymethyl)phenyl]-4-oxo-3,4-dihydrophthalazine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 773837-37-9
sodium cyanide

: 1242156-61-1
6-tert-butyl-2-(3-chloro-2-(hydroxymethyl)phenyl)-8-fluorophthalazin-1(2H)-one

: 1413063-83-8
7-tert-butyl-3-[3-chloro-2-(hydroxymethyl)phenyl]-4-oxo-3,4-dihydrophthalazine-5-carbonitrile

Guidance literature:: In dimethyl sulfoxide; at 80 ℃; for 76h;

Reference yield: 37.4%

: 1413063-83-8
7-tert-butyl-3-[3-chloro-2-(hydroxymethyl)phenyl]-4-oxo-3,4-dihydrophthalazine-5-carbonitrile

: 1413063-88-3
7-tert-butyl-3-[3-chloro-2-(hydroxymethyl)phenyl]-4-oxo-3,4-dihydrophthalazine-5-carbaldehyde

Guidance literature:: 7-tert-butyl-3-[3-chloro-2-(hydroxymethyl)phenyl]-4-oxo-3,4-dihydrophthalazine-5-carbonitrile; With diisobutylaluminium hydride; In toluene; for 1h; Cooling with ice;

With hydrogenchloride; water; In toluene; for 0.166667h;

Reference yield:

: 1413063-83-8
7-tert-butyl-3-[3-chloro-2-(hydroxymethyl)phenyl]-4-oxo-3,4-dihydrophthalazine-5-carbonitrile

: 1413061-25-2
4-[3-(6-tert-butyl-8-hydroxymethyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / toluene / 1 h / Cooling with ice

1.2: 0.17 h

2.1: sodium tetrahydroborate; methanol / 1,2-dichloro-ethane / 4 h / 20 °C

3.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 1 h / 125 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; potassium phosphate; diisobutylaluminium hydride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; 1,2-dichloro-ethane; toluene;