Methyl 4-<4-(1-phenylpyrazolyl)>-2-thiazolylacetate hydrobromide

Base Information

• Chemical Name: Methyl 4-<4-(1-phenylpyrazolyl)>-2-thiazolylacetate hydrobromide
• CAS No.: 137813-14-0
• Molecular Formula: BrH*C₁₅H₁₃N₃O₂S
• Molecular Weight: 380.265
• Mol file: 137813-14-0.mol

Synonyms:Methyl 4-<4-(1-phenylpyrazolyl)>-2-thiazolylacetate hydrobromide

Chemical Property of Methyl 4-<4-(1-phenylpyrazolyl)>-2-thiazolylacetate hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 4-<4-(1-phenylpyrazolyl)>-2-thiazolylacetate hydrobromide

There total 5 articles about Methyl 4-<4-(1-phenylpyrazolyl)>-2-thiazolylacetate hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1-Phenyl-4-(2-bromoacetyl)pyrazole (91062-67-8) + 2-(carbomethoxy)thioacetamide (689-09-8) → Methyl 4-<4-(1-phenylpyrazolyl)>-2-thiazolylacetate hydrobromide (137813-14-0)

Guidance literature:

In acetone; for 3h; Heating;

DOI:10.1002/jhet.5570280625

Reference yield:

4-carboxy-1-phenylpyrazole (1134-50-5) → Methyl 4-<4-(1-phenylpyrazolyl)>-2-thiazolylacetate hydrobromide (137813-14-0)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / 0.5 h / Heating

2: diethyl ether / 0 °C

3: HBr (gas) / diethyl ether / 0.5 h

4: 66 percent / acetone / 3 h / Heating

With thionyl chloride; hydrogen bromide; In diethyl ether; acetone;

DOI:10.1002/jhet.5570280625

Reference yield:

ethyl 1-phenylpyrazole-4-carboxylate (885-94-9) → Methyl 4-<4-(1-phenylpyrazolyl)>-2-thiazolylacetate hydrobromide (137813-14-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 99 percent / 2 N sodium hydroxide / ethanol / 0.5 h / 90 °C

2: thionyl chloride / 0.5 h / Heating

3: diethyl ether / 0 °C

4: HBr (gas) / diethyl ether / 0.5 h

5: 66 percent / acetone / 3 h / Heating

With sodium hydroxide; thionyl chloride; hydrogen bromide; In diethyl ether; ethanol; acetone;

DOI:10.1002/jhet.5570280625

upstream raw materials:

1-Phenyl-4-(2-bromoacetyl)pyrazole

2-(carbomethoxy)thioacetamide

4-carboxy-1-phenylpyrazole

ethyl 1-phenylpyrazole-4-carboxylate

Downstream raw materials:

4-<4-(1-Phenylpyrazolyl)>-2-thiazolylacetic acid